Histopathologic effects of transarterial bucrylate occlusion of intracerebral arteries in mongrel dogs

Bucrylate was injected directly into the cerebral cortical arteries of mongrel dogs. Preparations for light and electron microscopy were obtained from 5 min to 5 months after the introduction of the polymer. A mixed pattern of damage to arterial endothelium was seen, including electron microscopic d...

Full description

Saved in:
Bibliographic Details
Published in:American journal of neuroradiology : AJNR 1983-05, Vol.4 (3), p.385-387
Main Authors: Kish, KK, Rapp, SM, Wilner, HI, Wolfe, D, Thomas, LM, Barr, J
Format: Article
Language:English
Subjects:
Animals
Brain Ischemia - chemically induced
Bucrylate - adverse effects
Cerebral Arteries - drug effects
Cyanoacrylates - adverse effects
Dogs
Endothelium - drug effects
Intracranial Embolism and Thrombosis - chemically induced
Microscopy, Electron
Muscle, Smooth, Vascular - drug effects
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bucrylate was injected directly into the cerebral cortical arteries of mongrel dogs. Preparations for light and electron microscopy were obtained from 5 min to 5 months after the introduction of the polymer. A mixed pattern of damage to arterial endothelium was seen, including electron microscopic documentation of stripping away of the endothelium. Acute effects include a subocclusive thrombogenic matrix, which causes partial or complete thrombosis. The long-term reactions are those of a chronic inflammatory response to a foreign body.
ISSN:0195-6108
1936-959X