Roles of MicroRNAs in Peripheral Artery In-Stent Restenosis after Endovascular Treatment

Endovascular repair including percutaneous transluminal angioplasty (PTA) and stent implantation has become the standard approach for the treatment of peripheral arterial disease; however, restenosis is still the main limited complication for the long-term success of the endovascular repair. Endothe...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021, p.1-11
Main Authors: Wang, Mo, Zhang, Weichang, Zhang, Lei, Wang, Lunchang, Li, Jiehua, Shu, Chang, Li, Xin
Format: Article
Language:English
Subjects:
Analysis
Angioplasty
Apoptosis
Arteries
Biomarkers
Blood platelets
Cardiovascular disease
Cardiovascular system
Care and treatment
Carotid arteries
Complications and side effects
Denudation
Diagnosis
Diseases
Endothelium
Endovascular stents
Enzymes
Gene expression
Growth factors
Health aspects
Health services
Hyperplasia
Implants
Inflammation
Inflammatory response
MicroRNA
MicroRNAs
miRNA
Pathophysiology
Patient outcomes
Peripheral vascular diseases
Physiological aspects
Regeneration
Relapse
Repair
Restenosis
Review
Risk factors
RNA polymerase
Stenosis
Stents
Surgical implants
Target recognition
Therapeutic targets
Transluminal angioplasty
Veins & arteries
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Summary:Endovascular repair including percutaneous transluminal angioplasty (PTA) and stent implantation has become the standard approach for the treatment of peripheral arterial disease; however, restenosis is still the main limited complication for the long-term success of the endovascular repair. Endothelial denudation and regeneration, inflammatory response, and neointimal hyperplasia are major pathological processes occurring during in-stent restenosis (ISR). MicroRNAs exhibit great potential in regulating several vascular biological events in different cell types and have been identified as novel therapeutic targets as well as biomarkers for ISR prevention. This review summarized recent experimental and clinical studies on the role of miRNAs in ISR modification, with the aim of unraveling the underlying mechanism and potential therapeutic strategy of ISR.
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/9935671