Intracranial vascular calcifications, glioblastoma multiforme, and lead poisoning

A 72-year-man with previous lead poisoning presented with raised intracranial pressure and localizing neurologic signs. CT scans showed a high-grade glioma and extensive intracranial calcifications, which proved to be vascular in distribution on postmortem examination. The latter findings support th...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 1997-03, Vol.18 (3), p.576-579
Main Authors: Teo, JG, Goh, KY, Ahuja, A, Ng, HK, Poon, WS
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Brain Neoplasms - blood supply
Brain Neoplasms - diagnosis
Brain Neoplasms - pathology
Calcinosis - diagnosis
Calcinosis - pathology
Case Reports
Cerebral Arteries - pathology
Cerebrovascular Disorders - diagnosis
Cerebrovascular Disorders - pathology
Chemical and industrial products toxicology. Toxic occupational diseases
Diagnosis, Differential
Glioblastoma - blood supply
Glioblastoma - diagnosis
Glioblastoma - pathology
Humans
Intracranial Pressure - physiology
Lead Poisoning - diagnosis
Lead Poisoning - pathology
Male
Medical sciences
Metals and various inorganic compounds
Neurologic Examination
Toxicology
Tropical medicine
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Summary:A 72-year-man with previous lead poisoning presented with raised intracranial pressure and localizing neurologic signs. CT scans showed a high-grade glioma and extensive intracranial calcifications, which proved to be vascular in distribution on postmortem examination. The latter findings support the concept of dystrophic calcification following lead-induced cerebrovascular injury. Lead poisoning should be considered in the differential diagnosis of unexplained intracranial calcifications. There is also evidence from previous studies to suggest a causative relationship between lead poisoning and development of glioma.
ISSN:0195-6108
1936-959X