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Abnormal temporal lobe metabolism in violent subjects: correlation of imaging and neuropsychiatric findings
To search for metabolic correlates of clinical and electrophysiological abnormalities in violent subjects. Seven subjects with histories of extremely violent behavior were studied with positron emission tomography (PET) with fludeoxyglucose F 18 (FDG), brain electrical area mapping, MR imaging, neur...
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| Published in: | American journal of neuroradiology : AJNR 1997-04, Vol.18 (4), p.625-631 |
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| container_title | American journal of neuroradiology : AJNR |
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| creator | Seidenwurm, D Pounds, TR Globus, A Valk, PE |
| description | To search for metabolic correlates of clinical and electrophysiological abnormalities in violent subjects.
Seven subjects with histories of extremely violent behavior were studied with positron emission tomography (PET) with fludeoxyglucose F 18 (FDG), brain electrical area mapping, MR imaging, neuropsychiatric and neuropsychological testing, and clinical examination during medical evaluation associated with legal proceedings. Nine control subjects without evidence of organic brain disease were also studied with FDG-PET. Quantitative PET data were calculated as standardized uptake values comparing the highest occipital region with the lowest temporal region.
Temporal lobe metabolism was decreased in the study group relative to the control subjects. Medial temporal lobe metabolism was 39% lower than that in the occipital cortex in study subjects and only 27% lower than that in control subjects. These groups differed by Mann-Whitney U test and Wilcoxon's two-sample test. Metabolic differences correlated with limbic neuropsychiatric and electrophysiological abnormalities in the violent group.
In this selected population of violent subjects, FDG-PET scans showed metabolic abnormalities in the temporal lobes. These abnormalities correlated with limbic abnormalities seen at electrophysiological and neuropsychiatric evaluation. |
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Seven subjects with histories of extremely violent behavior were studied with positron emission tomography (PET) with fludeoxyglucose F 18 (FDG), brain electrical area mapping, MR imaging, neuropsychiatric and neuropsychological testing, and clinical examination during medical evaluation associated with legal proceedings. Nine control subjects without evidence of organic brain disease were also studied with FDG-PET. Quantitative PET data were calculated as standardized uptake values comparing the highest occipital region with the lowest temporal region.
Temporal lobe metabolism was decreased in the study group relative to the control subjects. Medial temporal lobe metabolism was 39% lower than that in the occipital cortex in study subjects and only 27% lower than that in control subjects. These groups differed by Mann-Whitney U test and Wilcoxon's two-sample test. Metabolic differences correlated with limbic neuropsychiatric and electrophysiological abnormalities in the violent group.
In this selected population of violent subjects, FDG-PET scans showed metabolic abnormalities in the temporal lobes. These abnormalities correlated with limbic abnormalities seen at electrophysiological and neuropsychiatric evaluation.</description><identifier>ISSN: 0195-6108</identifier><identifier>EISSN: 1936-959X</identifier><identifier>PMID: 9127022</identifier><identifier>CODEN: AAJNDL</identifier><language>eng</language><publisher>Oak Brook, IL: Am Soc Neuroradiology</publisher><subject>Adolescent ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Biological Psychiatry ; Brain Diseases - diagnosis ; Brain Diseases - physiopathology ; Comparative Study ; Deoxyglucose - analogs & derivatives ; Electroencephalography ; Female ; Fluorine Radioisotopes ; Fluorodeoxyglucose F18 ; Forensic Psychiatry ; Hippocampus - physiopathology ; Humans ; Limbic System - physiopathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Memory Disorders - diagnosis ; Neurocognitive Disorders - diagnosis ; Neurocognitive Disorders - metabolism ; Neurocognitive Disorders - physiopathology ; Neurocognitive Disorders - psychology ; Neuropsychological Tests ; Occipital Lobe - diagnostic imaging ; Occipital Lobe - metabolism ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiopharmaceuticals ; Social behavior disorders. Criminal behavior. Delinquency ; Temporal Lobe - diagnostic imaging ; Temporal Lobe - metabolism ; Tomography, Emission-Computed ; Violence - psychology</subject><ispartof>American journal of neuroradiology : AJNR, 1997-04, Vol.18 (4), p.625-631</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright © American Society of Neuroradiology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338482/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338482/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2647196$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9127022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seidenwurm, D</creatorcontrib><creatorcontrib>Pounds, TR</creatorcontrib><creatorcontrib>Globus, A</creatorcontrib><creatorcontrib>Valk, PE</creatorcontrib><title>Abnormal temporal lobe metabolism in violent subjects: correlation of imaging and neuropsychiatric findings</title><title>American journal of neuroradiology : AJNR</title><addtitle>AJNR Am J Neuroradiol</addtitle><description>To search for metabolic correlates of clinical and electrophysiological abnormalities in violent subjects.
Seven subjects with histories of extremely violent behavior were studied with positron emission tomography (PET) with fludeoxyglucose F 18 (FDG), brain electrical area mapping, MR imaging, neuropsychiatric and neuropsychological testing, and clinical examination during medical evaluation associated with legal proceedings. Nine control subjects without evidence of organic brain disease were also studied with FDG-PET. Quantitative PET data were calculated as standardized uptake values comparing the highest occipital region with the lowest temporal region.
Temporal lobe metabolism was decreased in the study group relative to the control subjects. Medial temporal lobe metabolism was 39% lower than that in the occipital cortex in study subjects and only 27% lower than that in control subjects. These groups differed by Mann-Whitney U test and Wilcoxon's two-sample test. Metabolic differences correlated with limbic neuropsychiatric and electrophysiological abnormalities in the violent group.
In this selected population of violent subjects, FDG-PET scans showed metabolic abnormalities in the temporal lobes. These abnormalities correlated with limbic abnormalities seen at electrophysiological and neuropsychiatric evaluation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Biological Psychiatry</subject><subject>Brain Diseases - diagnosis</subject><subject>Brain Diseases - physiopathology</subject><subject>Comparative Study</subject><subject>Deoxyglucose - analogs & derivatives</subject><subject>Electroencephalography</subject><subject>Female</subject><subject>Fluorine Radioisotopes</subject><subject>Fluorodeoxyglucose F18</subject><subject>Forensic Psychiatry</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Limbic System - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory Disorders - diagnosis</subject><subject>Neurocognitive Disorders - diagnosis</subject><subject>Neurocognitive Disorders - metabolism</subject><subject>Neurocognitive Disorders - physiopathology</subject><subject>Neurocognitive Disorders - psychology</subject><subject>Neuropsychological Tests</subject><subject>Occipital Lobe - diagnostic imaging</subject><subject>Occipital Lobe - metabolism</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiopharmaceuticals</subject><subject>Social behavior disorders. Criminal behavior. Delinquency</subject><subject>Temporal Lobe - diagnostic imaging</subject><subject>Temporal Lobe - metabolism</subject><subject>Tomography, Emission-Computed</subject><subject>Violence - psychology</subject><issn>0195-6108</issn><issn>1936-959X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpVUU1LxDAULKLo-vEThBzUW6FJ81UPgohfIHhR8BaSNNlG02RN2l389wZcRE_vwQwz8-btVAvYtbTuSPe2Wy0a2JGawoYfVIc5vzdNQzqG9qv9DiLWILSoPq5ViGmUHkxmXMVUFh-VAaOZpIre5RG4ANYuehMmkGf1bvSUL4GOKRkvJxcDiBa4US5dWAIZehDMnOIqf-nBySk5DawLfQHzcbVnpc_mZDuPqte725ebh_rp-f7x5vqpHloCpxojTBmSSjcIMqI5MxpyixmHRGEuacs72JBeUa57hRHBylLFGMe9tcgS0h5VVz-6q1mNptcleblLrFJJmb5ElE78R4IbxDKuBW9bjjkqAhdbgRQ_Z5MnMbqsjfcymDhnAWmLeem2EE__Ov1abOst-NkWl1lLb5MM2uVfGqKYwY4W2vkPbXDLYeOSEbl8xBdRKDabDeQCC4pI-w3aFZSD</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Seidenwurm, D</creator><creator>Pounds, TR</creator><creator>Globus, A</creator><creator>Valk, PE</creator><general>Am Soc Neuroradiology</general><general>American Society of Neuroradiology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>19970401</creationdate><title>Abnormal temporal lobe metabolism in violent subjects: correlation of imaging and neuropsychiatric findings</title><author>Seidenwurm, D ; Pounds, TR ; Globus, A ; Valk, PE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h351t-424672abc02175c87ec18f47815b48a6389105db68cdb4254bf6b7784dff2f553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Biological Psychiatry</topic><topic>Brain Diseases - diagnosis</topic><topic>Brain Diseases - physiopathology</topic><topic>Comparative Study</topic><topic>Deoxyglucose - analogs & derivatives</topic><topic>Electroencephalography</topic><topic>Female</topic><topic>Fluorine Radioisotopes</topic><topic>Fluorodeoxyglucose F18</topic><topic>Forensic Psychiatry</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Limbic System - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory Disorders - diagnosis</topic><topic>Neurocognitive Disorders - diagnosis</topic><topic>Neurocognitive Disorders - metabolism</topic><topic>Neurocognitive Disorders - physiopathology</topic><topic>Neurocognitive Disorders - psychology</topic><topic>Neuropsychological Tests</topic><topic>Occipital Lobe - diagnostic imaging</topic><topic>Occipital Lobe - metabolism</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiopharmaceuticals</topic><topic>Social behavior disorders. Criminal behavior. Delinquency</topic><topic>Temporal Lobe - diagnostic imaging</topic><topic>Temporal Lobe - metabolism</topic><topic>Tomography, Emission-Computed</topic><topic>Violence - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seidenwurm, D</creatorcontrib><creatorcontrib>Pounds, TR</creatorcontrib><creatorcontrib>Globus, A</creatorcontrib><creatorcontrib>Valk, PE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of neuroradiology : AJNR</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seidenwurm, D</au><au>Pounds, TR</au><au>Globus, A</au><au>Valk, PE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal temporal lobe metabolism in violent subjects: correlation of imaging and neuropsychiatric findings</atitle><jtitle>American journal of neuroradiology : AJNR</jtitle><addtitle>AJNR Am J Neuroradiol</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>18</volume><issue>4</issue><spage>625</spage><epage>631</epage><pages>625-631</pages><issn>0195-6108</issn><eissn>1936-959X</eissn><coden>AAJNDL</coden><abstract>To search for metabolic correlates of clinical and electrophysiological abnormalities in violent subjects.
Seven subjects with histories of extremely violent behavior were studied with positron emission tomography (PET) with fludeoxyglucose F 18 (FDG), brain electrical area mapping, MR imaging, neuropsychiatric and neuropsychological testing, and clinical examination during medical evaluation associated with legal proceedings. Nine control subjects without evidence of organic brain disease were also studied with FDG-PET. Quantitative PET data were calculated as standardized uptake values comparing the highest occipital region with the lowest temporal region.
Temporal lobe metabolism was decreased in the study group relative to the control subjects. Medial temporal lobe metabolism was 39% lower than that in the occipital cortex in study subjects and only 27% lower than that in control subjects. These groups differed by Mann-Whitney U test and Wilcoxon's two-sample test. Metabolic differences correlated with limbic neuropsychiatric and electrophysiological abnormalities in the violent group.
In this selected population of violent subjects, FDG-PET scans showed metabolic abnormalities in the temporal lobes. These abnormalities correlated with limbic abnormalities seen at electrophysiological and neuropsychiatric evaluation.</abstract><cop>Oak Brook, IL</cop><pub>Am Soc Neuroradiology</pub><pmid>9127022</pmid><tpages>7</tpages></addata></record> |
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| ispartof | American journal of neuroradiology : AJNR, 1997-04, Vol.18 (4), p.625-631 |
| issn | 0195-6108 1936-959X |
| language | eng |
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| source | PubMed Central |
| subjects | Adolescent Adult Adult and adolescent clinical studies Biological and medical sciences Biological Psychiatry Brain Diseases - diagnosis Brain Diseases - physiopathology Comparative Study Deoxyglucose - analogs & derivatives Electroencephalography Female Fluorine Radioisotopes Fluorodeoxyglucose F18 Forensic Psychiatry Hippocampus - physiopathology Humans Limbic System - physiopathology Magnetic Resonance Imaging Male Medical sciences Memory Disorders - diagnosis Neurocognitive Disorders - diagnosis Neurocognitive Disorders - metabolism Neurocognitive Disorders - physiopathology Neurocognitive Disorders - psychology Neuropsychological Tests Occipital Lobe - diagnostic imaging Occipital Lobe - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiopharmaceuticals Social behavior disorders. Criminal behavior. Delinquency Temporal Lobe - diagnostic imaging Temporal Lobe - metabolism Tomography, Emission-Computed Violence - psychology |
| title | Abnormal temporal lobe metabolism in violent subjects: correlation of imaging and neuropsychiatric findings |
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