Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds

Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and the treatment of chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process characterized by a series of progressive and irreversi...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-07, Vol.18 (15), p.8044
Main Authors: Figuer, Andrea, Bodega, Guillermo, Tato, Patricia, Valera, Gemma, Serroukh, Nadia, Ceprian, Noemi, de Sequera, Patricia, Morales, Enrique, Carracedo, Julia, Ramírez, Rafael, Alique, Matilde
Format: Article
Language:English
Subjects:
Age
Aging
Chronic illnesses
Coronaviruses
Developed countries
Diabetes
Frailty
Geriatrics
Homeostasis
Hypertension
Infectious diseases
Kidney diseases
Kidneys
Life expectancy
Life span
Metabolism
Mortality
Oxidative stress
Physiology
Population
Review
Risk factors
Sarcopenia
Senescence
Weight control
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Summary:Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and the treatment of chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process characterized by a series of progressive and irreversible physiological changes associated with loss of functional, psychological, and social capabilities. Numerous factors, such as oxidative stress, inflammation, and cellular senescence, and an irreversible geriatric syndrome known as frailty, contribute to human body deterioration in aging. The speed of aging may differ between individuals depending on the presence or absence of multiple factors (genetic and/or environment) and the subsequent misbalance of homeostasis, together with the increase of frailty, which also plays a key role in developing chronic diseases. In addition, pathological circumstances have been reported to precipitate or accelerate the aging process. This review investigated the mechanisms involved in the developing pathologies, particularly chronic kidney disease, associated with aging.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18158044