The Relationship between the Urinary Cadmium Concentration and Cause-Specific Mortality in Subjects without Severe Renal Damage: A 35-Year Follow-Up Study in a Cadmium-Polluted Area of Japan

We evaluated the association between urinary cadmium concentration (uCd, μg/g Cr) and risk of cause-specific mortality according to urinary β2-microglobulin (MG) concentration. Participants were 1383 male and 1700 female inhabitants of the Cd-polluted Kakehashi River basin. The uCd and β2-MG were ev...

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Published in:International journal of environmental research and public health 2021-07, Vol.18 (15), p.7747
Main Authors: Sakurai, Masaru, Suwazono, Yasushi, Nishijo, Muneko, Nogawa, Kazuhiro, Watanabe, Yuuka, Yoneda, Kazuka, Ishizaki, Masao, Morikawa, Yuko, Kido, Teruhiko, Nakagawa, Hideaki
Format: Article
Language:English
Subjects:
Cadmium
Cancer
Cardiovascular disease
Cardiovascular diseases
Cohort analysis
Confidence intervals
Death
Digestive system diseases
Health risks
Heart diseases
Heart failure
Kidney diseases
Mortality
Pneumonia
Population
Risk
River basins
Statistical analysis
Tumors
Vital statistics
Water pollution
Womens health
β2 Microglobulin
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Summary:We evaluated the association between urinary cadmium concentration (uCd, μg/g Cr) and risk of cause-specific mortality according to urinary β2-microglobulin (MG) concentration. Participants were 1383 male and 1700 female inhabitants of the Cd-polluted Kakehashi River basin. The uCd and β2-MG were evaluated in a survey in 1981–1982, where those participants were followed-up over 35 years later. Among the participants with a urinary β2-MG < 1000, the hazard ratios (HRs) (95% confidence interval) for mortality were significantly higher in those with a uCd of ≥10.0 compared with
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18157747