Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice

Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection....

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Bibliographic Details
Published in:The Journal of experimental medicine 2021-10, Vol.218 (10)
Main Authors: Bohrer, Andrea C, Castro, Ehydel, Hu, Zhidong, Queiroz, Artur T L, Tocheny, Claire E, Assmann, Maike, Sakai, Shunsuke, Nelson, Christine, Baker, Paul J, Ma, Hui, Wang, Lin, Zilu, Wen, du Bruyn, Elsa, Riou, Catherine, Kauffman, Keith D, Moore, Ian N, Del Nonno, Franca, Petrone, Linda, Goletti, Delia, Martineau, Adrian R, Lowe, David M, Cronan, Mark R, Wilkinson, Robert J, Barry, Clifton E, Via, Laura E, Barber, Daniel L, Klion, Amy D, Andrade, Bruno B, Song, Yanzheng, Wong, Ka-Wing, Mayer-Barber, Katrin D
Format: Article
Language:English
Subjects:
Adult
Animals
Brief Definitive Report
Eosinophils - physiology
Female
Granulocytes - microbiology
Granulocytes - physiology
Host-Pathogen Interactions - physiology
Humans
Infectious Disease and Host Defense
Innate Immunity and Inflammation
Latent Tuberculosis - microbiology
Lung - microbiology
Lung - pathology
Macaca mulatta
Male
Mice
Mice, Mutant Strains
Mucosal Immunology
Mycobacterium tuberculosis - pathogenicity
Tuberculosis - drug therapy
Tuberculosis - microbiology
Tuberculosis - pathology
Zebrafish - microbiology
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Summary:Host resistance to Mycobacterium tuberculosis (Mtb) infection requires the activities of multiple leukocyte subsets, yet the roles of the different innate effector cells during tuberculosis are incompletely understood. Here we uncover an unexpected association between eosinophils and Mtb infection. In humans, eosinophils are decreased in the blood but enriched in resected human tuberculosis lung lesions and autopsy granulomas. An influx of eosinophils is also evident in infected zebrafish, mice, and nonhuman primate granulomas, where they are functionally activated and degranulate. Importantly, using complementary genetic models of eosinophil deficiency, we demonstrate that in mice, eosinophils are required for optimal pulmonary bacterial control and host survival after Mtb infection. Collectively, our findings uncover an unexpected recruitment of eosinophils to the infected lung tissue and a protective role for these cells in the control of Mtb infection in mice.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20210469