Increased Pericardial Adipose Tissue in Smokers

Background: Pericardial adipose tissue (PAT), a visceral fat depot directly located to the heart, is associated with atherosclerotic and inflammatory processes. The extent of PAT is related to the prevalence of coronary heart disease and might be used for cardiovascular risk prediction. This study a...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-07, Vol.10 (15), p.3382
Main Authors: Zimmermann, Gregor S., Ruether, Tobias, von Ziegler, Franz, Greif, Martin, Tittus, Janine, Schenzle, Jan, Becker, Christoph, Becker, Alexander
Format: Article
Language:English
Subjects:
Atherosclerosis
Body fat
Cardiovascular disease
Clinical medicine
Coronary vessels
Diabetes
Heart
Metabolism
Pulmonary arteries
Risk factors
Smoking
Statistical analysis
Tomography
Tumor necrosis factor-TNF
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Summary:Background: Pericardial adipose tissue (PAT), a visceral fat depot directly located to the heart, is associated with atherosclerotic and inflammatory processes. The extent of PAT is related to the prevalence of coronary heart disease and might be used for cardiovascular risk prediction. This study aimed to determine the effect of smoking on the extent of PAT. Methods: We retrospectively examined 1217 asymptomatic patients (490 females, age 58.3 ± 8.3 years, smoker n = 573, non-smoker n = 644) with a multislice CT scanner and determined the PAT volume. Coronary risk factors were determined at inclusion, and a multivariate analysis was performed to evaluate the influence of smoking on PAT independent from accompanying risk factors. Results: The mean PAT volume was 215 ± 107 mL in all patients. The PAT volume in smokers was significantly higher compared to PAT volume in non-smokers (231 ± 104 mL vs. 201 ± 99 mL, p = 0.03). Patients without cardiovascular risk factors showed a significantly lower PAT volume (153 ± 155 mL, p < 0.05) compared to patients with more than 1 risk factor. Odds ratio was 2.92 [2.31, 3.61; p < 0.001] for elevated PAT in smokers. Conclusion: PAT as an individual marker of atherosclerotic activity and inflammatory burden was elevated in smokers. The finding was independent from metabolic risk factors and might therefore illustrate the increased inflammatory activity in smokers in comparison to non-smokers.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10153382