Design and Synthesis of Fluoro Analogues of Vitamin D

The discovery of a large variety of functions of vitamin D3 and its metabolites has led to the design and synthesis of a vast amount of vitamin D3 analogues in order to increase the potency and reduce toxicity. The introduction of highly electronegative fluorine atom(s) into vitamin D3 skeletons alt...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-08, Vol.22 (15), p.8191
Main Authors: Kawagoe, Fumihiro, Mototani, Sayuri, Kittaka, Atsushi
Format: Article
Language:English
Subjects:
Biological activity
Drug dosages
Electronegativity
Fluorine
Metabolism
Metabolites
Molecular structure
Oxidation
Proteins
Review
Toxicity
Vitamin D
Vitamin D3
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Summary:The discovery of a large variety of functions of vitamin D3 and its metabolites has led to the design and synthesis of a vast amount of vitamin D3 analogues in order to increase the potency and reduce toxicity. The introduction of highly electronegative fluorine atom(s) into vitamin D3 skeletons alters their physical and chemical properties. To date, many fluorinated vitamin D3 analogues have been designed and synthesized. This review summarizes the molecular structures of fluoro-containing vitamin D3 analogues and their synthetic methodologies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22158191