Protective role of 17β-estradiol treatment in renal injury on female rats submitted to brain death

Clinical and experimental data highlight the consequences of brain death on the quality of organs and demonstrate the importance of donor state to the results of transplantation. Female rats show higher cardio-pulmonary injury linked to decreased concentrations of female sex hormones after brain-dea...

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Published in:Annals of translational medicine 2021-07, Vol.9 (14), p.1125-1125
Main Authors: Armstrong-Jr, Roberto, Ricardo-da-Silva, Fernanda Yamamoto, Vidal-Dos-Santos, Marina, Correia, Cristiano de Jesus, Anunciação, Lucas Ferreira, Coutinho E Silva, Raphael Dos Santos, Moreira, Luiz Felipe Pinho, Leuvenink, Henri Gerrit Derk, Breithaupt-Faloppa, Ana Cristina
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Language:English
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Summary:Clinical and experimental data highlight the consequences of brain death on the quality of organs and demonstrate the importance of donor state to the results of transplantation. Female rats show higher cardio-pulmonary injury linked to decreased concentrations of female sex hormones after brain-dead (BD). This study evaluated the effect of 17β-estradiol on brain death induced renal injury in female rats. Female Wistar rats were randomically allocated into 4 groups: false-operation (Sham), BD, treatment with 17β-estradiol (50 µg/mL, 2 mL/h) 3 h after brain death (E2-T3), or immediately after brain death confirmation (E2-T0). Creatinine, urea, cytokines, and complement system components were quantified. Renal injury markers, such as KIM-1, Caspase-3, BCL-2 and MMP2/9 were evaluated. Brain death leads to increased kidney KIM-1 expression and longer 17β-estradiol treatment resulted in downregulation (P
ISSN:2305-5839
2305-5839
DOI:10.21037/atm-21-1408