Prediction of COVID Criticality Score with Laboratory, Clinical and CT Images using Hybrid Regression Models

• Published in: Computer methods and programs in biomedicine 2021-09, Vol.209, p.106336-106336, Article 106336
• Main Authors: Perumal, Varalakshmi, Narayanan, Vasumathi, Rajasekar, Sakthi Jaya Sundar
• Format: Article
• Language: English
• Subjects: Chest CT images; Clinical features; Convolutional neural network (CNN); COVID Criticality score; COVID-19; Humans; Laboratories; Laboratory features; Machine Learning; Regression models; SARS-CoV-2; Tomography, X-Ray Computed
• ISSN: 0169-2607; 1872-7565
• DOI: 10.1016/j.cmpb.2021.106336

•COVID-19 diagnosis must be made quickly and precisely in hotspot areas.•Motive of this proposed study is to look at the baseline, laboratory, and CT characteristics of COVID-19 patients in two classes (Early and Critical stages).•The proposed COVID-19 prediction model is based on the manifestations that characterise the seriousness of the disease. Background and Objective: Rapid and precise diagnosis of COVID-19 is very critical in hotspot regions. The main aim of this proposed work is to investigate the baseline, laboratory and CT features of COVID-19 affected patients of two groups (Early and Critical stages). The detection model for COVID-19 is built depending upon the manifestations that define the severity of the disease. Methods: The CT scan images are fed into the various deep learning, machine learning and hybrid learning models to mine the necessary features and predict CT Score. The predicted CT score along with other clinical, laboratory and CT scan image features are then passed to train the various Regression models for predicting the COVID Criticality (CC) Score. These baseline, laboratory and CT features of COVID-19 are reduced using Statistical analysis and Univariate logistic regression analysis. Results: When analysing the prediction of CT scores using images alone, AlexNet+Lasso yields better outcome with regression score of 0.9643 and RMSE of 0.0023 when compared with Decision tree (RMSE of 0.0034; Regression score of 0.9578) and GRU (RMSE of 0.1253; regression score of 0.9323). When analysing the prediction of CC scores using CT scores and other baseline, laboratory and CT features, VGG-16+Linear Regression yields better results with regression score of 0.9911 and RMSE of 0.0002 when compared with Linear SVR (RMSE of 0.0006; Regression score of 0.9911) and LSTM (RMSE of 0.0005; Regression score of 0.9877). The correlation analysis is performed to identify the significance of utilizing other features in prediction of CC Score. The correlation coefficient of CT scores with actual value is 0.93 and 0.92 for Early stage group and Critical stage group respectively. The correlation coefficient of CC scores with actual value is 0.96 for Early stage group and 0.95 for Critical stage group.The classification of COVID-19 patients are carried out with the help of predicted CC Scores. Conclusions: This proposed work is carried out in the motive of helping radiologists in faster categorization of COVID patients as Early or Severe staged using CC S