Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass

• Published in: Sovremennye tekhnologii v medit͡s︡ine 2021-01, Vol.13 (1), p.71-75
• Main Authors: Danilova, D A, Brichkin, Yu D, Medvedev, A P, Pichugin, V V, Fedorov, S A, Taranov, E V, Nazarov, E I, Ryazanov, M V, Bolshukhin, G V, Deryugina, A V
• Format: Article
• Language: English
• Subjects: Anesthesia; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Clinical Supplements; Female; Heart Valve Diseases; Humans; Hydrogen; Male
• ISSN: 2076-4243; 2309-995X
• DOI: 10.17691/stm2021.13.1.09

was to study the effect of molecular hydrogen on oxidative processes in cardiac surgery patients with acquired valve heart disease applied during surgery under cardiopulmonary bypass (CPB). The study involved 20 patients (16 men and 4 women) with acquired heart valve disease who were operated on under CPB. Two groups of patients were formed. In group 1 (n=11), anesthesia included inhalations of molecular hydrogen, which was supplied to the breathing circuit of the ventilator at a concentration of 1.5-2.0% immediately after tracheal intubation and throughout the operation. In group 2 (n=9), inhalation of molecular hydrogen was not performed. Blood sampling was taken at 4 stages: immediately after anesthesia induction, before CPB and after its termination, and also one day after the operation. The intensity of the processes of lipid peroxidation was evaluated by the level of diene (DC) and triene (TC) conjugates, Schiff bases (SB). In the patients of group 1, the arterial blood samples showed a decrease in the level of TC and SB, as compared to the first stage of the study, before the initiation of CPB and one day after the operation. An increase in the level of DC and TC was detected after the termination of CPB (p