The impact of hyperbaric oxygen therapy on late radiation toxicity and quality of life in breast cancer patients

Purpose To evaluate symptoms of late radiation toxicity, side effects, and quality of life in breast cancer patients treated with hyperbaric oxygen therapy (HBOT). Methods For this cohort study breast cancer patients treated with HBOT in 5 Dutch facilities were eligible for inclusion. Breast cancer...

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Bibliographic Details
Published in:Breast cancer research and treatment 2021-09, Vol.189 (2), p.425-433
Main Authors: Batenburg, Marilot C. T., Maarse, Wies, van der Leij, Femke, Baas, Inge O., Boonstra, Onno, Lansdorp, Nina, Doeksen, Annemiek, van den Bongard, Desiree H. J. G., Verkooijen, Helena M.
Format: Article
Language:English
Subjects:
Breast cancer
Cancer
Cancer patients
Cancer research
Cancer therapies
Care and treatment
Clinical Trial
Hyperbaric oxygen therapy
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Myopia
Oncology
Oxygen therapy
Pain
Patients
Quality of life
Radiation
Radiation therapy
Radiotherapy
Side effects
Toxicity
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Summary:Purpose To evaluate symptoms of late radiation toxicity, side effects, and quality of life in breast cancer patients treated with hyperbaric oxygen therapy (HBOT). Methods For this cohort study breast cancer patients treated with HBOT in 5 Dutch facilities were eligible for inclusion. Breast cancer patients with late radiation toxicity treated with ≥ 20 HBOT sessions from 2015 to 2019 were included. Breast and arm symptoms, pain, and quality of life were assessed by means of the EORTC QLQ-C30 and -BR23 before, immediately after, and 3 months after HBOT on a scale of 0–100. Determinants associated with persistent breast pain after HBOT were assessed. Results 1005/1280 patients were included for analysis. Pain scores decreased significantly from 43.4 before HBOT to 29.7 after 3 months ( p  
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-021-06332-2