Rhododendrol‐induced leukoderma update II: Pathophysiology, mechanisms, risk evaluation, and possible mechanism‐based treatments in comparison with vitiligo

A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo. In this review, we investigate and evaluate the major considerations for developing rhododendrol‐induced leukoderma...

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Bibliographic Details
Published in:Journal of dermatology 2021-07, Vol.48 (7), p.969-978
Main Authors: Inoue, Shintaro, Katayama, Ichiro, Suzuki, Tamio, Tanemura, Atsushi, Ito, Shosuke, Abe, Yuko, Sumikawa, Yasuyuki, Yoshikawa, Momoko, Suzuki, Kayoko, Yagami, Akiko, Masui, Yukiko, Ito, Akiko, Matsunaga, Kayoko
Format: Article
Language:English
Subjects:
Cosmetics
Cytotoxicity
Health risks
Immune system
Leukoderma
melanocyte
Organic chemicals
Oxidative stress
Pathophysiology
Review
rhododendrol
Side effects
Vitiligo
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Summary:A small proportion of individuals utilizing cosmetics containing rhododendrol developed leukoderma with various pathological conditions, in some cases indistinguishable from vitiligo. In this review, we investigate and evaluate the major considerations for developing rhododendrol‐induced leukoderma based on data from original or review articles published in the literature to provide a wide range of information regarding the pathophysiology, mechanisms, risk evaluation, and possible mechanism‐based treatments. We compile and discuss the latest information, including data related to the cytotoxicity of rhododendrol, cytoprotective functions, and involvement of the immune system, and consider the possibility of novel treatments based on the differences between individual patients and on the mechanism underlying the onset of the condition. Understanding the pathophysiology of rhododendrol‐induced leukoderma helps not only elucidate the mechanisms of non‐segmental vitiligo onset and progression, but also suggests prevention and treatment.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.15878