Association of sleep disturbance with calcitonin, disease severity and health index among patients with ankylosing spondylitis

To investigate the association of sleep disturbance with calcium regulatory hormones, disease severity and health index among the patients with ankylosing spondylitis (AS).There were 104 AS patients enrolled in the cross-sectional study, and their sleep quality was recorded. Serum levels of calcium,...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-08, Vol.100 (32), p.e26934-e26934
Main Authors: Chen, Chun-Hsiung, Chen, Hung-An, Liao, Hsien-Tzung, Chen, Chen-Hung
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Calcitonin - blood
Cross-Sectional Studies
Follow-Up Studies
Health Status
Humans
Incidence
Middle Aged
Observational Study
Retrospective Studies
Risk Assessment - methods
Severity of Illness Index
Sleep - physiology
Sleep Wake Disorders - epidemiology
Sleep Wake Disorders - etiology
Sleep Wake Disorders - physiopathology
Spondylitis, Ankylosing - blood
Spondylitis, Ankylosing - complications
Spondylitis, Ankylosing - physiopathology
Taiwan
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Summary:To investigate the association of sleep disturbance with calcium regulatory hormones, disease severity and health index among the patients with ankylosing spondylitis (AS).There were 104 AS patients enrolled in the cross-sectional study, and their sleep quality was recorded. Serum levels of calcium, parathyroid hormone, vitamin D3 and calcitonin were measured. We evaluated patient's disease activity, functional ability, patient's global assessment, physical mobility, radiographic damage and health index. Blood ESR and CRP levels were tested.Sleep quality was positively correlated with serum calcitonin levels (r = 0.260, P = .008). Bad sleep and advanced radiographic damage were found among the AS patients with detectable serum calcitonin levels (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000026934