Association of sleep disturbance with calcitonin, disease severity and health index among patients with ankylosing spondylitis

To investigate the association of sleep disturbance with calcium regulatory hormones, disease severity and health index among the patients with ankylosing spondylitis (AS).There were 104 AS patients enrolled in the cross-sectional study, and their sleep quality was recorded. Serum levels of calcium,...

Full description

Saved in:
Bibliographic Details
Published in:Medicine (Baltimore) 2021-08, Vol.100 (32), p.e26934-e26934
Main Authors: Chen, Chun-Hsiung, Chen, Hung-An, Liao, Hsien-Tzung, Chen, Chen-Hung
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Calcitonin - blood
Cross-Sectional Studies
Follow-Up Studies
Health Status
Humans
Incidence
Middle Aged
Observational Study
Retrospective Studies
Risk Assessment - methods
Severity of Illness Index
Sleep - physiology
Sleep Wake Disorders - epidemiology
Sleep Wake Disorders - etiology
Sleep Wake Disorders - physiopathology
Spondylitis, Ankylosing - blood
Spondylitis, Ankylosing - complications
Spondylitis, Ankylosing - physiopathology
Taiwan
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4505-ce90d5df39f3e895d17dd67db835c205fb7c4baa4fcabdc4e045b4df2406de9d3
cites cdi_FETCH-LOGICAL-c4505-ce90d5df39f3e895d17dd67db835c205fb7c4baa4fcabdc4e045b4df2406de9d3
container_end_page e26934
container_issue 32
container_start_page e26934
container_title Medicine (Baltimore)
container_volume 100
creator Chen, Chun-Hsiung
Chen, Hung-An
Liao, Hsien-Tzung
Chen, Chen-Hung
description To investigate the association of sleep disturbance with calcium regulatory hormones, disease severity and health index among the patients with ankylosing spondylitis (AS).There were 104 AS patients enrolled in the cross-sectional study, and their sleep quality was recorded. Serum levels of calcium, parathyroid hormone, vitamin D3 and calcitonin were measured. We evaluated patient's disease activity, functional ability, patient's global assessment, physical mobility, radiographic damage and health index. Blood ESR and CRP levels were tested.Sleep quality was positively correlated with serum calcitonin levels (r = 0.260, P = .008). Bad sleep and advanced radiographic damage were found among the AS patients with detectable serum calcitonin levels (P 
doi_str_mv 10.1097/MD.0000000000026934
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8360431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2561924868</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4505-ce90d5df39f3e895d17dd67db835c205fb7c4baa4fcabdc4e045b4df2406de9d3</originalsourceid><addsrcrecordid>eNpdkU1vFSEUhonR2Gv1F5gYli6cCgMMw8akaf1K2rjRNWHgTC-WCyPM9Ho3_napU-vH2ZzkvO95OOFF6DklJ5Qo-fry_IT8qbZTjD9AGypY1wjV8YdoU6eikUryI_SklK-EUCZb_hgdMc6UVJxu0I_TUpL1ZvYp4jTiEgAm7HyZlzyYaAHv_bzF1gTr5xR9fHUrgimAC9xA9vMBm-jwFkyoPh8dfMdml-IVnioU4lxWgonXh5CKr0KZUnSH4GdfnqJHowkFnt31Y_Tl3dvPZx-ai0_vP56dXjSWCyIaC4o44UamRga9Eo5K5zrphp4J2xIxDtLywRg-WjM4y4FwMXA3tpx0DpRjx-jNyp2WYQfO1ruyCXrKfmfyQSfj9b9K9Ft9lW50zzrCGa2Al3eAnL4tUGa988VCCCZCWopuRUdVy_uur1a2Wm1OpWQY75-hRN8mpy_P9f_J1a0Xf194v_M7qmrgq2Gfwgy5XIdlD1mvH_-LJ6Rqm5a0lPSUkaZOpGA_AbmfqRQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2561924868</pqid></control><display><type>article</type><title>Association of sleep disturbance with calcitonin, disease severity and health index among patients with ankylosing spondylitis</title><source>PubMed Central Free</source><source>IngentaConnect Journals</source><source>Lippincott Williams &amp; Wilkins</source><creator>Chen, Chun-Hsiung ; Chen, Hung-An ; Liao, Hsien-Tzung ; Chen, Chen-Hung</creator><creatorcontrib>Chen, Chun-Hsiung ; Chen, Hung-An ; Liao, Hsien-Tzung ; Chen, Chen-Hung</creatorcontrib><description>To investigate the association of sleep disturbance with calcium regulatory hormones, disease severity and health index among the patients with ankylosing spondylitis (AS).There were 104 AS patients enrolled in the cross-sectional study, and their sleep quality was recorded. Serum levels of calcium, parathyroid hormone, vitamin D3 and calcitonin were measured. We evaluated patient's disease activity, functional ability, patient's global assessment, physical mobility, radiographic damage and health index. Blood ESR and CRP levels were tested.Sleep quality was positively correlated with serum calcitonin levels (r = 0.260, P = .008). Bad sleep and advanced radiographic damage were found among the AS patients with detectable serum calcitonin levels (P &lt; .05). Sleep quality was significantly correlated with disease duration, CRP, BASDAI, ASDAS-ESR, ASDAS-CRP, BASFI, BAS-G, BASMI and ASAS-HI among the AS patients (all P &lt; .05). Female gender, longer disease duration, higher ASDAS-CRP and serum calcitonin levels (OR [95% CI] = 3.210 [1.012-10.181], P = .048) were independent factors associated with bad sleep. Inflammation, disease activity, functional ability, patient's global assessment and cervical rotation were useful in predicting bad sleep among the AS patients, and ASDAS-CRP was the best predictor (AUC = 0.772, P &lt; .001).Serum calcitonin levels was elevated in the AS patients with bad sleep, and may participate in the pathophysiology of sleep disturbance. Bad sleep was associated with female gender, longer disease duration, higher inflammation, disease activity, functional impairment, mobility restriction, poor patient's global assessment and health index in AS. ASDAS-CRP was best in predicting bad sleep.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000026934</identifier><identifier>PMID: 34397941</identifier><language>eng</language><publisher>United States: Lippincott Williams &amp; Wilkins</publisher><subject>Adult ; Biomarkers - blood ; Calcitonin - blood ; Cross-Sectional Studies ; Follow-Up Studies ; Health Status ; Humans ; Incidence ; Middle Aged ; Observational Study ; Retrospective Studies ; Risk Assessment - methods ; Severity of Illness Index ; Sleep - physiology ; Sleep Wake Disorders - epidemiology ; Sleep Wake Disorders - etiology ; Sleep Wake Disorders - physiopathology ; Spondylitis, Ankylosing - blood ; Spondylitis, Ankylosing - complications ; Spondylitis, Ankylosing - physiopathology ; Taiwan</subject><ispartof>Medicine (Baltimore), 2021-08, Vol.100 (32), p.e26934-e26934</ispartof><rights>Lippincott Williams &amp; Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4505-ce90d5df39f3e895d17dd67db835c205fb7c4baa4fcabdc4e045b4df2406de9d3</citedby><cites>FETCH-LOGICAL-c4505-ce90d5df39f3e895d17dd67db835c205fb7c4baa4fcabdc4e045b4df2406de9d3</cites><orcidid>0000-0002-5619-6466 ; 0000-0003-3774-7039</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360431/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8360431/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34397941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Chun-Hsiung</creatorcontrib><creatorcontrib>Chen, Hung-An</creatorcontrib><creatorcontrib>Liao, Hsien-Tzung</creatorcontrib><creatorcontrib>Chen, Chen-Hung</creatorcontrib><title>Association of sleep disturbance with calcitonin, disease severity and health index among patients with ankylosing spondylitis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>To investigate the association of sleep disturbance with calcium regulatory hormones, disease severity and health index among the patients with ankylosing spondylitis (AS).There were 104 AS patients enrolled in the cross-sectional study, and their sleep quality was recorded. Serum levels of calcium, parathyroid hormone, vitamin D3 and calcitonin were measured. We evaluated patient's disease activity, functional ability, patient's global assessment, physical mobility, radiographic damage and health index. Blood ESR and CRP levels were tested.Sleep quality was positively correlated with serum calcitonin levels (r = 0.260, P = .008). Bad sleep and advanced radiographic damage were found among the AS patients with detectable serum calcitonin levels (P &lt; .05). Sleep quality was significantly correlated with disease duration, CRP, BASDAI, ASDAS-ESR, ASDAS-CRP, BASFI, BAS-G, BASMI and ASAS-HI among the AS patients (all P &lt; .05). Female gender, longer disease duration, higher ASDAS-CRP and serum calcitonin levels (OR [95% CI] = 3.210 [1.012-10.181], P = .048) were independent factors associated with bad sleep. Inflammation, disease activity, functional ability, patient's global assessment and cervical rotation were useful in predicting bad sleep among the AS patients, and ASDAS-CRP was the best predictor (AUC = 0.772, P &lt; .001).Serum calcitonin levels was elevated in the AS patients with bad sleep, and may participate in the pathophysiology of sleep disturbance. Bad sleep was associated with female gender, longer disease duration, higher inflammation, disease activity, functional impairment, mobility restriction, poor patient's global assessment and health index in AS. ASDAS-CRP was best in predicting bad sleep.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Calcitonin - blood</subject><subject>Cross-Sectional Studies</subject><subject>Follow-Up Studies</subject><subject>Health Status</subject><subject>Humans</subject><subject>Incidence</subject><subject>Middle Aged</subject><subject>Observational Study</subject><subject>Retrospective Studies</subject><subject>Risk Assessment - methods</subject><subject>Severity of Illness Index</subject><subject>Sleep - physiology</subject><subject>Sleep Wake Disorders - epidemiology</subject><subject>Sleep Wake Disorders - etiology</subject><subject>Sleep Wake Disorders - physiopathology</subject><subject>Spondylitis, Ankylosing - blood</subject><subject>Spondylitis, Ankylosing - complications</subject><subject>Spondylitis, Ankylosing - physiopathology</subject><subject>Taiwan</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpdkU1vFSEUhonR2Gv1F5gYli6cCgMMw8akaf1K2rjRNWHgTC-WCyPM9Ho3_napU-vH2ZzkvO95OOFF6DklJ5Qo-fry_IT8qbZTjD9AGypY1wjV8YdoU6eikUryI_SklK-EUCZb_hgdMc6UVJxu0I_TUpL1ZvYp4jTiEgAm7HyZlzyYaAHv_bzF1gTr5xR9fHUrgimAC9xA9vMBm-jwFkyoPh8dfMdml-IVnioU4lxWgonXh5CKr0KZUnSH4GdfnqJHowkFnt31Y_Tl3dvPZx-ai0_vP56dXjSWCyIaC4o44UamRga9Eo5K5zrphp4J2xIxDtLywRg-WjM4y4FwMXA3tpx0DpRjx-jNyp2WYQfO1ruyCXrKfmfyQSfj9b9K9Ft9lW50zzrCGa2Al3eAnL4tUGa988VCCCZCWopuRUdVy_uur1a2Wm1OpWQY75-hRN8mpy_P9f_J1a0Xf194v_M7qmrgq2Gfwgy5XIdlD1mvH_-LJ6Rqm5a0lPSUkaZOpGA_AbmfqRQ</recordid><startdate>20210813</startdate><enddate>20210813</enddate><creator>Chen, Chun-Hsiung</creator><creator>Chen, Hung-An</creator><creator>Liao, Hsien-Tzung</creator><creator>Chen, Chen-Hung</creator><general>Lippincott Williams &amp; Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5619-6466</orcidid><orcidid>https://orcid.org/0000-0003-3774-7039</orcidid></search><sort><creationdate>20210813</creationdate><title>Association of sleep disturbance with calcitonin, disease severity and health index among patients with ankylosing spondylitis</title><author>Chen, Chun-Hsiung ; Chen, Hung-An ; Liao, Hsien-Tzung ; Chen, Chen-Hung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4505-ce90d5df39f3e895d17dd67db835c205fb7c4baa4fcabdc4e045b4df2406de9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Calcitonin - blood</topic><topic>Cross-Sectional Studies</topic><topic>Follow-Up Studies</topic><topic>Health Status</topic><topic>Humans</topic><topic>Incidence</topic><topic>Middle Aged</topic><topic>Observational Study</topic><topic>Retrospective Studies</topic><topic>Risk Assessment - methods</topic><topic>Severity of Illness Index</topic><topic>Sleep - physiology</topic><topic>Sleep Wake Disorders - epidemiology</topic><topic>Sleep Wake Disorders - etiology</topic><topic>Sleep Wake Disorders - physiopathology</topic><topic>Spondylitis, Ankylosing - blood</topic><topic>Spondylitis, Ankylosing - complications</topic><topic>Spondylitis, Ankylosing - physiopathology</topic><topic>Taiwan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chun-Hsiung</creatorcontrib><creatorcontrib>Chen, Hung-An</creatorcontrib><creatorcontrib>Liao, Hsien-Tzung</creatorcontrib><creatorcontrib>Chen, Chen-Hung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chun-Hsiung</au><au>Chen, Hung-An</au><au>Liao, Hsien-Tzung</au><au>Chen, Chen-Hung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of sleep disturbance with calcitonin, disease severity and health index among patients with ankylosing spondylitis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-08-13</date><risdate>2021</risdate><volume>100</volume><issue>32</issue><spage>e26934</spage><epage>e26934</epage><pages>e26934-e26934</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>To investigate the association of sleep disturbance with calcium regulatory hormones, disease severity and health index among the patients with ankylosing spondylitis (AS).There were 104 AS patients enrolled in the cross-sectional study, and their sleep quality was recorded. Serum levels of calcium, parathyroid hormone, vitamin D3 and calcitonin were measured. We evaluated patient's disease activity, functional ability, patient's global assessment, physical mobility, radiographic damage and health index. Blood ESR and CRP levels were tested.Sleep quality was positively correlated with serum calcitonin levels (r = 0.260, P = .008). Bad sleep and advanced radiographic damage were found among the AS patients with detectable serum calcitonin levels (P &lt; .05). Sleep quality was significantly correlated with disease duration, CRP, BASDAI, ASDAS-ESR, ASDAS-CRP, BASFI, BAS-G, BASMI and ASAS-HI among the AS patients (all P &lt; .05). Female gender, longer disease duration, higher ASDAS-CRP and serum calcitonin levels (OR [95% CI] = 3.210 [1.012-10.181], P = .048) were independent factors associated with bad sleep. Inflammation, disease activity, functional ability, patient's global assessment and cervical rotation were useful in predicting bad sleep among the AS patients, and ASDAS-CRP was the best predictor (AUC = 0.772, P &lt; .001).Serum calcitonin levels was elevated in the AS patients with bad sleep, and may participate in the pathophysiology of sleep disturbance. Bad sleep was associated with female gender, longer disease duration, higher inflammation, disease activity, functional impairment, mobility restriction, poor patient's global assessment and health index in AS. ASDAS-CRP was best in predicting bad sleep.</abstract><cop>United States</cop><pub>Lippincott Williams &amp; Wilkins</pub><pmid>34397941</pmid><doi>10.1097/MD.0000000000026934</doi><orcidid>https://orcid.org/0000-0002-5619-6466</orcidid><orcidid>https://orcid.org/0000-0003-3774-7039</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0025-7974
ispartof Medicine (Baltimore), 2021-08, Vol.100 (32), p.e26934-e26934
issn 0025-7974
1536-5964
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8360431
source PubMed Central Free; IngentaConnect Journals; Lippincott Williams & Wilkins
subjects Adult
Biomarkers - blood
Calcitonin - blood
Cross-Sectional Studies
Follow-Up Studies
Health Status
Humans
Incidence
Middle Aged
Observational Study
Retrospective Studies
Risk Assessment - methods
Severity of Illness Index
Sleep - physiology
Sleep Wake Disorders - epidemiology
Sleep Wake Disorders - etiology
Sleep Wake Disorders - physiopathology
Spondylitis, Ankylosing - blood
Spondylitis, Ankylosing - complications
Spondylitis, Ankylosing - physiopathology
Taiwan
title Association of sleep disturbance with calcitonin, disease severity and health index among patients with ankylosing spondylitis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T13%3A01%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20sleep%20disturbance%20with%20calcitonin,%20disease%20severity%20and%20health%20index%20among%20patients%20with%20ankylosing%20spondylitis&rft.jtitle=Medicine%20(Baltimore)&rft.au=Chen,%20Chun-Hsiung&rft.date=2021-08-13&rft.volume=100&rft.issue=32&rft.spage=e26934&rft.epage=e26934&rft.pages=e26934-e26934&rft.issn=0025-7974&rft.eissn=1536-5964&rft_id=info:doi/10.1097/MD.0000000000026934&rft_dat=%3Cproquest_pubme%3E2561924868%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4505-ce90d5df39f3e895d17dd67db835c205fb7c4baa4fcabdc4e045b4df2406de9d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2561924868&rft_id=info:pmid/34397941&rfr_iscdi=true