Targeting JP2: A New Treatment for Pulmonary Hypertension

Pulmonary hypertension (PH) is a disease with a complex etiology and high mortality rate. Abnormal pulmonary vasoconstriction and pulmonary vascular remodeling lead to an increase in mean pulmonary arterial blood pressure for which, and there is currently no cure. Junctophilin-2 (JP2) is beneficial...

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Published in:Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.2003446-2003446
Main Authors: Tan, Rubin, Li, Cui, Xu, Chuan, Wu, Qi, Gao, Liping, Shi, Yue, Cui, Jie
Format: Article
Language:English
Subjects:
Amino acids
Calcium - metabolism
Cell Membrane - metabolism
Heart
Homeostasis
Humans
Hydroxamic Acids - therapeutic use
Hypertension, Pulmonary - drug therapy
Hypertension, Pulmonary - metabolism
Hypertension, Pulmonary - pathology
Hypoxia
Kinases
Localization
Membrane Proteins - antagonists & inhibitors
Membrane Proteins - metabolism
Muscle contraction
Muscle Proteins - antagonists & inhibitors
Muscle Proteins - metabolism
Muscle, Smooth, Vascular - metabolism
Myocardial Contraction
Myocardium - metabolism
Proteins
Pulmonary hypertension
Review
Sarcoplasmic Reticulum - metabolism
Smooth muscle
Sulfones - therapeutic use
Transcription factors
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Summary:Pulmonary hypertension (PH) is a disease with a complex etiology and high mortality rate. Abnormal pulmonary vasoconstriction and pulmonary vascular remodeling lead to an increase in mean pulmonary arterial blood pressure for which, and there is currently no cure. Junctophilin-2 (JP2) is beneficial for the assembly of junctional membrane complexes, the structural basis for excitation-contraction coupling that tethers the plasma membrane to the sarcoplasmic reticulum/endoplasmic reticulum and is involved in maintaining intracellular calcium concentration homeostasis and normal muscle contraction function. Recent studies have shown that JP2 maintains normal contraction and relaxation of vascular smooth muscle. In some experimental studies of drug treatments for PH, JP2 expression was increased, which improved pulmonary vascular remodeling and right ventricular function. Based on JP2 research to date, this paper summarizes the current understanding of JP2 protein structure, function, and related heart diseases and mechanisms and analyzes the feasibility and possible therapeutic strategies for targeting JP2 in PH.
ISSN:1942-0900
1942-0994
DOI:10.1155/2021/2003446