Maternal vascular endothelial growth factor receptor and interleukin levels in pregnant women with twin-twin transfusion syndrome

Twin-twin transfusion syndrome (TTTS) is an unusual and serious condition that occurs in twin pregnancies when identical twins share a placenta but develop discordant amniotic fluid volumes. TTTS is associated with an increased risk of fetal death and birth defects if untreated. This study investiga...

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Bibliographic Details
Published in:International journal of medical sciences 2021-01, Vol.18 (14), p.3206-3213
Main Authors: Anh, Nguyen Duy, Thuong, Phan Huyen, Sim, Nguyen Thi, Thao, Tran Thi Phuong, Anh, Luong Thi Lan, Canh, Than Thi Thu, Dieu, Nguyen Van, Bac, Nguyen Duy, Tong, Hoang Van
Format: Article
Language:English
Subjects:
Adult
Amniotic fluid
Biomarkers - blood
Blood transfusions
Blood vessels
Cytokines
Female
Fetofetal Transfusion - diagnosis
Fetofetal Transfusion - surgery
Fetuses
Gynecology
Humans
Interleukin-1beta - blood
Interleukin-6 - blood
Interleukin-6 - metabolism
Interleukin-8 - blood
Investigations
Laboratories
Obstetrics
Pathogenesis
Placenta - blood supply
Placenta - metabolism
Plasma
Pregnancy
Pregnancy Trimester, First - blood
Pregnancy Trimester, Second - blood
Pregnancy, Twin - blood
Premature birth
Prognosis
Research Paper
Twins
Twins, Monozygotic
Ultrasonic imaging
Vascular endothelial growth factor
Vascular Endothelial Growth Factor Receptor-1 - blood
Vascular Endothelial Growth Factor Receptor-1 - metabolism
Vascular Endothelial Growth Factor Receptor-2 - blood
Vascular Endothelial Growth Factor Receptor-2 - metabolism
Veins & arteries
Young Adult
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Summary:Twin-twin transfusion syndrome (TTTS) is an unusual and serious condition that occurs in twin pregnancies when identical twins share a placenta but develop discordant amniotic fluid volumes. TTTS is associated with an increased risk of fetal death and birth defects if untreated. This study investigated the soluble levels of biomarkers including growth factors and interleukins in pregnant women with and without TTTS during pregnancy. We quantified plasma levels of VEGF-R1, VEGF-R2, IL-1β, IL-6 and IL-8 in twin pregnant women with (n=53) and without TTTS (n=72) and in women with single pregnancy (n=30) by ELISA and analyzed the association of maternal circulating biomarker levels with TTTS. Our results showed that maternal VEGF-R1 levels were significantly higher in twins compared to single pregnancy (
ISSN:1449-1907
1449-1907
DOI:10.7150/ijms.61014