Supramolecular organization of rhodopsin in rod photoreceptor cell membranes

Rhodopsin is the light receptor in rod photoreceptor cells that initiates scotopic vision. Studies on the light receptor span well over a century, yet questions about the organization of rhodopsin within the photoreceptor cell membrane still persist and a consensus view on the topic is still elusive...

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Bibliographic Details
Published in:Pflügers Archiv 2021-09, Vol.473 (9), p.1361-1376
Main Author: Park, Paul S.-H.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Membrane - chemistry
Cell Membrane - metabolism
Cell membranes
Human Physiology
Humans
Invited Review
Membranes
Molecular Medicine
Neurosciences
Photoreceptors
Protein Multimerization - physiology
Protein Structure, Secondary
Receptors
Retinal Rod Photoreceptor Cells - chemistry
Retinal Rod Photoreceptor Cells - metabolism
Rhodopsin
Rhodopsin - chemistry
Rhodopsin - metabolism
Structure-function relationships
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Summary:Rhodopsin is the light receptor in rod photoreceptor cells that initiates scotopic vision. Studies on the light receptor span well over a century, yet questions about the organization of rhodopsin within the photoreceptor cell membrane still persist and a consensus view on the topic is still elusive. Rhodopsin has been intensely studied for quite some time, and there is a wealth of information to draw from to formulate an organizational picture of the receptor in native membranes. Early experimental evidence in apparent support for a monomeric arrangement of rhodopsin in rod photoreceptor cell membranes is contrasted and reconciled with more recent visual evidence in support of a supramolecular organization of rhodopsin. What is known so far about the determinants of forming a supramolecular structure and possible functional roles for such an organization are also discussed. Many details are still missing on the structural and functional properties of the supramolecular organization of rhodopsin in rod photoreceptor cell membranes. The emerging picture presented here can serve as a springboard towards a more in-depth understanding of the topic.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-021-02522-5