Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients

Immune-mediated myocardial injury following Severe Acute Respiratory Syndrome Coronavirys-2 (SARS-CoV2) infection has been described in adults and children. Cases of myocarditis following immunization for SARS-CoV2 have recently been documented, mostly associated with mild severity and spontaneous r...

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Bibliographic Details
Published in:International journal of cardiology 2021-10, Vol.340, p.119-121
Main Authors: Abbate, Antonio, Gavin, Josh, Madanchi, Nima, Kim, Christin, Shah, Pranav R., Klein, Katherine, Boatman, Julie, Roberts, Charlotte, Patel, Seema, Danielides, Stamatina
Format: Article
Language:English
Subjects:
Adult
BNT162 Vaccine
Child
Coronavirus
COVID-19
COVID-19 Vaccines
Humans
Myocarditis
Myocarditis - diagnosis
RNA, Messenger
RNA, Viral
SARS-CoV-2
Short Communication
Systemic Inflammatory Response Syndrome
Vaccination - adverse effects
Vaccine
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Summary:Immune-mediated myocardial injury following Severe Acute Respiratory Syndrome Coronavirys-2 (SARS-CoV2) infection has been described in adults and children. Cases of myocarditis following immunization for SARS-CoV2 have recently been documented, mostly associated with mild severity and spontaneous recovery. We herein report two cases of fulminant myocarditis following BNT162b2 mRNA Covid-19 vaccination associated with systemic hyperinflammatory syndrome and refractory shock requiring support with veno-arterial extracorporeal membrane oxygenation. •Fulminant myocarditis may occur following SARS-CoV2 mRNA vaccination requiring mechanical cardiac support.•It is important to recognize features of systemic hyperinflammatory syndrome following SARS-CoV2 mRNA vaccination.
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2021.08.018