Dynamic Rac1 inhibition by CYRI helps cells drink, but stops them from driving

In this issue, Le et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202012114) describe a new role for the recently discovered protein CYRI in controlling the protrusions that allow cells to engulf extracellular fluid by macropinocytosis. This study helps explain how these structures are disass...

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Bibliographic Details
Published in:The Journal of cell biology 2021-09, Vol.220 (9), p.1
Main Author: King, Jason S
Format: Article
Language:English
Subjects:
Cancer
Cytoskeleton
Pinocytosis
Rac1 protein
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Summary:In this issue, Le et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202012114) describe a new role for the recently discovered protein CYRI in controlling the protrusions that allow cells to engulf extracellular fluid by macropinocytosis. This study helps explain how these structures are disassembled, but also uncovers a new mechanism linking the ability of cells to drink and their capacity for invasive migration.
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202108041