Mining Natural Products with Anticancer Biological Activity through a Systems Biology Approach

Natural products, like turmeric, are considered powerful antioxidants which exhibit tumor-inhibiting activity and chemoradioprotective properties. Nowadays, there is a great demand for developing novel, affordable, efficacious, and effective anticancer drugs from natural resources. In the present st...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.9993518
Main Authors: Theofylaktou, Dionysia, Takan, Işıl, Karakülah, Gökhan, Biz, Gökay Mehmet, Zanni, Vaso, Pavlopoulou, Athanasia, Georgakilas, Alexandros G.
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Antioxidants
Biological Products - pharmacology
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Cancer
Cell cycle
Computational Biology - methods
Dairy products
Fruits
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic - drug effects
Gene Regulatory Networks
Herbs
Humans
Natural & organic foods
Natural products
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Nuts
Organisms
Polyphenols
Prognosis
Proteins
Spices
Systems Biology - methods
User interface
Variance analysis
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Summary:Natural products, like turmeric, are considered powerful antioxidants which exhibit tumor-inhibiting activity and chemoradioprotective properties. Nowadays, there is a great demand for developing novel, affordable, efficacious, and effective anticancer drugs from natural resources. In the present study, we have employed a stringent in silico methodology to mine and finally propose a number of natural products, retrieved from the biomedical literature. Our main target was the systematic search of anticancer products as anticancer agents compatible to the human organism for future use. In this case and due to the great plethora of such products, we have followed stringent bioinformatics methodologies. Our results taken together suggest that natural products of a great diverse may exert cytotoxic effects in a maximum of the studied cancer cell lines. These natural compounds and active ingredients could possibly be combined to exert potential chemopreventive effects. Furthermore, in order to substantiate our findings and their application potency at a systems biology level, we have developed a representative, user-friendly, publicly accessible biodatabase, NaturaProDB, containing the retrieved natural resources, their active ingredients/fractional mixtures, the types of cancers that they affect, and the corresponding experimentally verified target genes.
ISSN:1942-0900
1942-0994
DOI:10.1155/2021/9993518