Current therapeutic options for gastric adenocarcinoma

Gastric cancer inflicts significant health issues globally despite its declining incidence. The disease is known to be diagnosed at its advanced stages also corresponding with a poor prognosis for patients. The integral therapeutic choices to cure advanced gastric cancer have progressed swiftly in m...

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Bibliographic Details
Published in:Saudi journal of biological sciences 2021-09, Vol.28 (9), p.5371-5378
Main Authors: Akshatha, C.R., Bhat, Smitha, Sindhu, R., Shashank, Dharini, Rose Sommano, Sarana, Tapingkae, Wanaporn, Cheewangkoon, Ratchadawan, Prasad, Shashanka K.
Format: Article
Language:English
Subjects:
Chemotherapy
Gastric cancer
Helicobacter pylori
MicroRNAs
Review
Therapeutics
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Summary:Gastric cancer inflicts significant health issues globally despite its declining incidence. The disease is known to be diagnosed at its advanced stages also corresponding with a poor prognosis for patients. The integral therapeutic choices to cure advanced gastric cancer have progressed swiftly in modern days. The preface of molecularly targeted therapeutic techniques would potentiate the personalized approach depending on patient-specific and tumor-specific features, exasperating the advantages of chemotherapy. Here we have reviewed the modern therapeutics such as immune therapy, chemotherapy, m-RNA based therapeutics, alongside evaluating the influence of age, sex and comorbidities-like factors on the occurrence of gastric cancer. Gastric cancer therapy consolidated target agents comprising inhibitors of programmed death-1(PD-1), human epidermal growth factor receptor 2 (HER2), mRNA, and epidermal growth factor receptor (EPGF). A combination of trastuzumab to platinum-mediated chemotherapy evolved has a typical front-line therapy in advanced gastric cancer. An attempt has been made to epitomize the contemporary-modern research on targeted therapy for advanced gastric cancer.
ISSN:1319-562X
2213-7106
DOI:10.1016/j.sjbs.2021.05.060