The impact of Ki-67 index, squamous differentiation, and several clinicopathologic parameters on the recurrence of low and intermediate-risk endometrial cancer

Endometrial endometrioid carcinoma (EEC) represents approximately 75-80% of endometrial carcinoma cases. Three hundred and thirty-six patients with EEC followed-up in the authors' medical center between 2010 and 2018 were included in our study. Two hundred and seventy-two low and intermediate E...

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Bibliographic Details
Published in:Biomolecules & biomedicine 2021-10, Vol.21 (5), p.549-554
Main Authors: Ocak, Birol, Atalay, Fatma Öz, Sahin, Ahmet Bilgehan, Ozsen, Mine, Dakiki, Bahar, Türe, Seray, Mesohorli, Merve, Odman, Hikmet Utku, Tanrıverdi, Özgür, Ocakoğlu, Gökhan, Bayrak, Mehmet, Ozan, Hakan, Demiröz, Candan, Sali, Seda, Orhan, Sibel Oyucu, Deligönül, Adem, Cubukcu, Erdem, Evrensel, Türkkan
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers, Tumor - blood
Cancer
Carcinoma, Squamous Cell - pathology
Case-Control Studies
Cell differentiation
Development and progression
Endometrial cancer
Endometrial Neoplasms - pathology
endometrioid endometrial carcinoma
Female
Health aspects
Humans
Ki-67
Ki-67 antigen
Ki-67 Antigen - blood
Low-intermediate risk
Middle Aged
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Recurrence, Local - epidemiology
Neoplasm Staging
Physiological aspects
Prognosis
recurrence
Relapse
Retrospective Studies
Risk Factors
squamous differentiation
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Summary:Endometrial endometrioid carcinoma (EEC) represents approximately 75-80% of endometrial carcinoma cases. Three hundred and thirty-six patients with EEC followed-up in the authors' medical center between 2010 and 2018 were included in our study. Two hundred and seventy-two low and intermediate EEC patients were identified using the European Society for Medical Oncology criteria and confirmed by histopathological examination. Recurrence was reported in 17 of these patients. The study group consisted of patients with relapse. A control group of 51 patients was formed at a ratio of 3:1 according to age, stage, and grade, similar to that in the study group. Of the 17 patients with recurrent disease, 13 patients (76.5%) were Stage 1A, and 4 patients (23.5%) were Stage 1B. No significant difference was found in age, stage, and grade between the case and control groups (p > 0.05). Body mass index, parity, tumor size, lower uterine segment involvement, SqD, and Ki-67 index with p
ISSN:1512-8601
2831-0896
1840-4812
2831-090X
DOI:10.17305/bjbms.2020.5437