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Trends of incidence and prognosis of upper tract urothelial carcinoma

The purpose of this study was to investigate trends in the incidence of upper tract urothelial carcinoma (UTUC) in patients and to establish a reliable and practical nomogram based on significant clinical factors to predict the overall survival (OS) and cancer-specific survival (CSS) of UTUC patient...

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Bibliographic Details
Published in:Bosnian journal of basic medical sciences 2021-10, Vol.21 (5), p.607-619
Main Authors: Wu, Jianping, Chen, Shuqiu, Wu, Xiaoli, Mao, Weipu, Wang, Yali, Xu, Bin, Zheng, Donghui, Chen, Ming
Format: Article
Language:English
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Summary:The purpose of this study was to investigate trends in the incidence of upper tract urothelial carcinoma (UTUC) in patients and to establish a reliable and practical nomogram based on significant clinical factors to predict the overall survival (OS) and cancer-specific survival (CSS) of UTUC patients. The Surveillance, Epidemiology, and End Results (SEER) database was used to extract data on UTUC patients between 1988 and 2015. Incidence was calculated using Joinpoint regression software, and trends were quantified by annual percentage change (APC). A nomogram was constructed using R software to predict the OS and CSS probabilities for individual patients. From 1988 to 2015, the incidence of UTUC showed a downward trend (1988: 1.57/100,000 to 2015: 1.51/100,000; APC=-0.1). After stratification according to sex, age and primary site, we found that the incidences of UTUC in males, patients 70+ years old and the renal pelvis were higher than those in females, patients
ISSN:1512-8601
1840-4812
DOI:10.17305/bjbms.2020.5345