The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer’s Disease

The increasing numbers of elderly Alzheimer’s disease (AD) patients because of a steady increase in the average lifespan and aging society attract great scientific concerns, while there were fewer effective treatments on AD progression due to unclear exact causes and pathogenesis of AD. Moderate (20...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.5568011-5568011
Main Authors: Zhou, Xiangyu, Zhang, Lin
Format: Article
Language:English
Subjects:
Age
Aged
Alcohol
Alzheimer Disease - metabolism
Alzheimer Disease - prevention & control
Alzheimer's disease
Animals
Caffeine
Caffeine - therapeutic use
Coffee
Cognitive ability
Dementia
Diabetes
Drug dosages
Exercise
Humans
Hypertension
Ischemia
Marital status
Neuroprotective Agents - therapeutic use
Physical fitness
Review
Risk Factors
Smoking
Tea
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Summary:The increasing numbers of elderly Alzheimer’s disease (AD) patients because of a steady increase in the average lifespan and aging society attract great scientific concerns, while there were fewer effective treatments on AD progression due to unclear exact causes and pathogenesis of AD. Moderate (200-500 mg/d) and regular caffeine consumption from coffee and tea are considered to alleviate the risk of AD and have therapeutic potential. This paper reviewed epidemiological studies about the relationship of caffeine intake from coffee or/and tea with the risk of AD and summarized the caffeine-related AD therapies based on experimental models. And further well-designed and well-conducted studies are suggested to investigate the optimal dosages, frequencies, and durations of caffeine consumption to slow down AD progression and treat AD.
ISSN:1942-0900
1942-0994
DOI:10.1155/2021/5568011