Exosomal lncRNA LINC01711 facilitates metastasis of esophageal squamous cell carcinoma via the miR-326/FSCN1 axis

Esophageal cancer is a malignant tumor with a five-year survival rate of less than 20%. Early diagnosis and exploration of esophageal cancer pathogenesis are of great significance for the treatment and prognosis of esophageal cancer. Long non-coding RNA (lncRNA) plays a vital role in the occurrence...

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Published in:Aging (Albany, NY.) NY.), 2021-08, Vol.13 (15), p.19776-19788
Main Authors: Xu, Mei-Ling, Liu, Tian-Cheng, Dong, Feng-Xiang, Meng, Ling-Xin, Ling, Ai-Xia, Liu, Shan
Format: Article
Language:English
Subjects:
Animals
Apoptosis - physiology
Carrier Proteins - metabolism
Cell Line, Tumor
Cell Movement - physiology
Cell Proliferation - physiology
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Esophageal Neoplasms - pathology
Esophageal Squamous Cell Carcinoma - genetics
Esophageal Squamous Cell Carcinoma - metabolism
Esophageal Squamous Cell Carcinoma - pathology
Gene Expression Regulation, Neoplastic
Heterografts
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Microfilament Proteins - metabolism
MicroRNAs - genetics
MicroRNAs - metabolism
Neoplasm Invasiveness
Prognosis
Research Paper
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Transfection
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Summary:Esophageal cancer is a malignant tumor with a five-year survival rate of less than 20%. Early diagnosis and exploration of esophageal cancer pathogenesis are of great significance for the treatment and prognosis of esophageal cancer. Long non-coding RNA (lncRNA) plays a vital role in the occurrence and development of different types of tumors. However, the role of exosome LncRNA in esophageal squamous cell carcinoma (ESCC) is rarely reported. In this study, we detected high expression of lncRNA LINC01711 in ESCC tissues and was associated with poor prognosis. Silencing LINC01711 can inhibit the proliferation, migration, invasion, and growth of ESCC cell lines, and induce apoptosis. Linc01711 was identified as a competitive endogenous RNA that suppressed miR-326, and up-regulated the expression of fascin actin-bundling protein 1 (FSCN1). Besides, experiments showed that the administration of exosome-derived LINC01711 (LINC01711-Exo) promoted the growth of tumors in nude mice. In general, exosomal LINC01711 promoted the proliferation, migration, and invasion of esophageal cancer cells by up-regulating FSCN1 and down-regulating miR-326, thus improved the occurrence and development of ESCC.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.203389