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In‐hospital outcomes of transcatheter mitral valve repair in patients with and without end stage renal disease: A national propensity match study

Objectives To study trends of utilization, outcomes, and cost of care in patients undergoing undergoing transcatheter mitral valve repair (TMVr) with end‐stage renal disease (ESRD). Background Renal disease has been known to be a predictor of poor outcome in patients with mitral valve disease. Outco...

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Published in:Catheterization and cardiovascular interventions 2021-08, Vol.98 (2), p.343-351
Main Authors: Khan, Muhammad Zia, Zahid, Salman, Khan, Muhammad U., Kichloo, Asim, Jamal, Shakeel, Minhas, Abdul Mannan Khan, Munir, Muhammad Bilal, Balla, Sudarshan
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container_title Catheterization and cardiovascular interventions
container_volume 98
creator Khan, Muhammad Zia
Zahid, Salman
Khan, Muhammad U.
Kichloo, Asim
Jamal, Shakeel
Minhas, Abdul Mannan Khan
Munir, Muhammad Bilal
Balla, Sudarshan
description Objectives To study trends of utilization, outcomes, and cost of care in patients undergoing undergoing transcatheter mitral valve repair (TMVr) with end‐stage renal disease (ESRD). Background Renal disease has been known to be a predictor of poor outcome in patients with mitral valve disease. Outcome data for patients with ESRD undergoing TMVr remains limited. Therefore, our study aims to investigate trends of utilization, outcomes, and cost of care among patients with ESRD undergoing TMVr. Methods We analyzed NIS data from January 2010 to December 2017 using the ICD‐9‐CM codes ICD‐10‐CM to identify patients who underwent TMVr. Baseline characteristics were compared using a Pearson χ2 test for categorical variables and independent samples t‐test for continuous variables. Propensity matched analysis was done for adjusted analysis to compare outcomes between TMVr with and without ESRD. Markov chain Monte Carlo was used to account for missing values. Results A total of 15,260 patients (weighted sample) undergoing TMVr were identified between 2010 and 2017. Of these, 638 patients had ESRD compared to 14,631 patients who did not have ESRD. Adjusted in‐hospital mortality was lower in non‐ESRD group (3.9 vs.
doi_str_mv 10.1002/ccd.29517
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Background Renal disease has been known to be a predictor of poor outcome in patients with mitral valve disease. Outcome data for patients with ESRD undergoing TMVr remains limited. Therefore, our study aims to investigate trends of utilization, outcomes, and cost of care among patients with ESRD undergoing TMVr. Methods We analyzed NIS data from January 2010 to December 2017 using the ICD‐9‐CM codes ICD‐10‐CM to identify patients who underwent TMVr. Baseline characteristics were compared using a Pearson χ2 test for categorical variables and independent samples t‐test for continuous variables. Propensity matched analysis was done for adjusted analysis to compare outcomes between TMVr with and without ESRD. Markov chain Monte Carlo was used to account for missing values. Results A total of 15,260 patients (weighted sample) undergoing TMVr were identified between 2010 and 2017. Of these, 638 patients had ESRD compared to 14,631 patients who did not have ESRD. Adjusted in‐hospital mortality was lower in non‐ESRD group (3.9 vs. &lt;1.8%). Similarly, ESRD patients were more likely to have non‐home discharges (85.6 vs. 74.9%). ESRD patients also had a longer mean length of stay (7.9 vs. 13.5 days) and higher mean cost of stay ($306,300 vs. $271,503). Conclusion ESRD is associated with higher mortality, complications, and resource utilization compared to non‐ESRD patients. It is important to include this data in shared decision‐making process and patient selection.</description><identifier>ISSN: 1522-1946</identifier><identifier>ISSN: 1522-726X</identifier><identifier>EISSN: 1522-726X</identifier><identifier>DOI: 10.1002/ccd.29517</identifier><identifier>PMID: 33527676</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley &amp; Sons, Inc</publisher><subject>Cardiac Catheterization - adverse effects ; Decision making ; end‐stage renal disease ; Heart Valve Prosthesis Implantation - adverse effects ; Hospitals ; Humans ; Kidney diseases ; Kidney Failure, Chronic - diagnosis ; Kidney Failure, Chronic - therapy ; Markov chains ; Mitral valve ; Mitral Valve - diagnostic imaging ; Mitral Valve - surgery ; Mitral Valve Insufficiency - surgery ; Mortality ; Patients ; percutaneous edge‐to‐edge mitral valve repair ; percutaneous mitral valve repair with clip ; Resource utilization ; Rheumatic heart disease ; Treatment Outcome ; Trends</subject><ispartof>Catheterization and cardiovascular interventions, 2021-08, Vol.98 (2), p.343-351</ispartof><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4437-83cd13e8463a48b8609aff2a75de778ba1ca39fc0058ab1701c336f3181c82763</citedby><cites>FETCH-LOGICAL-c4437-83cd13e8463a48b8609aff2a75de778ba1ca39fc0058ab1701c336f3181c82763</cites><orcidid>0000-0002-9804-898X ; 0000-0002-4452-6317 ; 0000-0001-8473-8069</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33527676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Muhammad Zia</creatorcontrib><creatorcontrib>Zahid, Salman</creatorcontrib><creatorcontrib>Khan, Muhammad U.</creatorcontrib><creatorcontrib>Kichloo, Asim</creatorcontrib><creatorcontrib>Jamal, Shakeel</creatorcontrib><creatorcontrib>Minhas, Abdul Mannan Khan</creatorcontrib><creatorcontrib>Munir, Muhammad Bilal</creatorcontrib><creatorcontrib>Balla, Sudarshan</creatorcontrib><title>In‐hospital outcomes of transcatheter mitral valve repair in patients with and without end stage renal disease: A national propensity match study</title><title>Catheterization and cardiovascular interventions</title><addtitle>Catheter Cardiovasc Interv</addtitle><description>Objectives To study trends of utilization, outcomes, and cost of care in patients undergoing undergoing transcatheter mitral valve repair (TMVr) with end‐stage renal disease (ESRD). Background Renal disease has been known to be a predictor of poor outcome in patients with mitral valve disease. Outcome data for patients with ESRD undergoing TMVr remains limited. Therefore, our study aims to investigate trends of utilization, outcomes, and cost of care among patients with ESRD undergoing TMVr. Methods We analyzed NIS data from January 2010 to December 2017 using the ICD‐9‐CM codes ICD‐10‐CM to identify patients who underwent TMVr. Baseline characteristics were compared using a Pearson χ2 test for categorical variables and independent samples t‐test for continuous variables. Propensity matched analysis was done for adjusted analysis to compare outcomes between TMVr with and without ESRD. Markov chain Monte Carlo was used to account for missing values. Results A total of 15,260 patients (weighted sample) undergoing TMVr were identified between 2010 and 2017. Of these, 638 patients had ESRD compared to 14,631 patients who did not have ESRD. Adjusted in‐hospital mortality was lower in non‐ESRD group (3.9 vs. &lt;1.8%). Similarly, ESRD patients were more likely to have non‐home discharges (85.6 vs. 74.9%). ESRD patients also had a longer mean length of stay (7.9 vs. 13.5 days) and higher mean cost of stay ($306,300 vs. $271,503). Conclusion ESRD is associated with higher mortality, complications, and resource utilization compared to non‐ESRD patients. 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Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Catheterization and cardiovascular interventions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Muhammad Zia</au><au>Zahid, Salman</au><au>Khan, Muhammad U.</au><au>Kichloo, Asim</au><au>Jamal, Shakeel</au><au>Minhas, Abdul Mannan Khan</au><au>Munir, Muhammad Bilal</au><au>Balla, Sudarshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In‐hospital outcomes of transcatheter mitral valve repair in patients with and without end stage renal disease: A national propensity match study</atitle><jtitle>Catheterization and cardiovascular interventions</jtitle><addtitle>Catheter Cardiovasc Interv</addtitle><date>2021-08-01</date><risdate>2021</risdate><volume>98</volume><issue>2</issue><spage>343</spage><epage>351</epage><pages>343-351</pages><issn>1522-1946</issn><issn>1522-726X</issn><eissn>1522-726X</eissn><abstract>Objectives To study trends of utilization, outcomes, and cost of care in patients undergoing undergoing transcatheter mitral valve repair (TMVr) with end‐stage renal disease (ESRD). Background Renal disease has been known to be a predictor of poor outcome in patients with mitral valve disease. Outcome data for patients with ESRD undergoing TMVr remains limited. Therefore, our study aims to investigate trends of utilization, outcomes, and cost of care among patients with ESRD undergoing TMVr. Methods We analyzed NIS data from January 2010 to December 2017 using the ICD‐9‐CM codes ICD‐10‐CM to identify patients who underwent TMVr. Baseline characteristics were compared using a Pearson χ2 test for categorical variables and independent samples t‐test for continuous variables. Propensity matched analysis was done for adjusted analysis to compare outcomes between TMVr with and without ESRD. Markov chain Monte Carlo was used to account for missing values. Results A total of 15,260 patients (weighted sample) undergoing TMVr were identified between 2010 and 2017. Of these, 638 patients had ESRD compared to 14,631 patients who did not have ESRD. Adjusted in‐hospital mortality was lower in non‐ESRD group (3.9 vs. &lt;1.8%). Similarly, ESRD patients were more likely to have non‐home discharges (85.6 vs. 74.9%). ESRD patients also had a longer mean length of stay (7.9 vs. 13.5 days) and higher mean cost of stay ($306,300 vs. $271,503). Conclusion ESRD is associated with higher mortality, complications, and resource utilization compared to non‐ESRD patients. It is important to include this data in shared decision‐making process and patient selection.</abstract><cop>Hoboken, USA</cop><pub>John Wiley &amp; Sons, Inc</pub><pmid>33527676</pmid><doi>10.1002/ccd.29517</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9804-898X</orcidid><orcidid>https://orcid.org/0000-0002-4452-6317</orcidid><orcidid>https://orcid.org/0000-0001-8473-8069</orcidid><oa>free_for_read</oa></addata></record>
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subjects Cardiac Catheterization - adverse effects
Decision making
end‐stage renal disease
Heart Valve Prosthesis Implantation - adverse effects
Hospitals
Humans
Kidney diseases
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - therapy
Markov chains
Mitral valve
Mitral Valve - diagnostic imaging
Mitral Valve - surgery
Mitral Valve Insufficiency - surgery
Mortality
Patients
percutaneous edge‐to‐edge mitral valve repair
percutaneous mitral valve repair with clip
Resource utilization
Rheumatic heart disease
Treatment Outcome
Trends
title In‐hospital outcomes of transcatheter mitral valve repair in patients with and without end stage renal disease: A national propensity match study
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