Endoscopy within 7 days after detecting high calprotectin levels can be useful for therapeutic decision-making in ulcerative colitis

The aim of this study was to assess the appropriate time interval to identify the association between the fecal calprotectin (FC) test and endoscopic activity, and to evaluate whether the time interval affects the therapeutic plan adjustment in patients with ulcerative colitis (UC).This study includ...

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Bibliographic Details
Published in:Medicine (Baltimore) 2021-08, Vol.100 (34), p.e27065-e27065
Main Authors: Yong, Ho Min, Park, Sung-Jo, Jeon, Seong Ran, Park, Heesu, Kim, Hyun Gun, Lee, Tae Hee, Park, Junseok, Kim, Jin-Oh, Lee, Joon Seong, Ko, Bong Min, Goong, Hyeon Jeong, Park, Suyeon
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Adult
Biological Products - therapeutic use
Biomarkers
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - pathology
Colonoscopy - methods
Feces - chemistry
Female
Humans
Leukocyte L1 Antigen Complex - analysis
Male
Middle Aged
Observational Study
Prospective Studies
Retrospective Studies
ROC Curve
Severity of Illness Index
Sulfasalazine - therapeutic use
Time-to-Treatment
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Summary:The aim of this study was to assess the appropriate time interval to identify the association between the fecal calprotectin (FC) test and endoscopic activity, and to evaluate whether the time interval affects the therapeutic plan adjustment in patients with ulcerative colitis (UC).This study included 103 patients who underwent FC tests and endoscopic examinations within the past three months. The FC test results classified cases into three groups as follows: moderate to severe (>200, >250, or >300 μg/g), mild (100-200, 100-250, or 100-300 μg/g), and inactive (
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000027065