Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Seroprevalence and Limited Clinical Disease in 3 Malian Communities: A Prospective Cohort Study

• Published in: Clinical infectious diseases 2022-03, Vol.74 (6), p.1030-1038
• Main Authors: Sagara, Issaka, Woodford, John, Kone, Mamady, Assadou, Mahamadoun Hamady, Katile, Abdoulaye, Attaher, Oumar, Zeguime, Amatigue, Doucoure, M’Bouye, Higbee, Emily, Lane, Jacquelyn, Mohan, Rathy, Doritchamou, Justin, Zaidi, Irfan, Esposito, Dominic, Kwan, Jennifer, Sadtler, Kaitlyn, Dicko, Alassane, Duffy, Patrick E
• Format: Article
• Language: English
• Subjects: Life Sciences; Major and Commentaries
• ISSN: 1058-4838; 1537-6591; 1537-6591
• DOI: 10.1093/cid/ciab589

Abstract Background The extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure and transmission in Mali and the surrounding region is not well understood. We aimed to estimate the cumulative incidence of SARS-CoV-2 in 3 communities and understand factors associated with infection. Methods Between July 2020 and January 2021, we collected blood samples and demographic, social, medical, and self-reported symptoms information from residents aged 6 months and older over 2 study visits. SARS-CoV-2 antibodies were measured using a highly specific 2-antigen enzyme-linked immunosorbent assay optimized for use in Mali. We calculated cumulative adjusted seroprevalence for each community and evaluated factors associated with serostatus at each visit by univariate and multivariate analysis. Results Overall, 94.8% (2533/2672) of participants completed both study visits. A total of 31.3% (837/2672) were aged