Cytoskeleton and Associated Proteins: Pleiotropic JNK Substrates and Regulators

This review extensively reports data from the literature concerning the complex relationships between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton elements, which are actin filaments, microtubules, intermediate filaments, and septins. To a lesser extent, we also...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-08, Vol.22 (16), p.8375
Main Authors: Benoit, Béatrice, Baillet, Anita, Poüs, Christian
Format: Article
Language:English
Subjects:
Actin
Actin Cytoskeleton - metabolism
Actins - metabolism
Animals
Binding sites
c-Jun protein
Cell cycle
Cytoskeletal Proteins - metabolism
Cytoskeleton
Cytoskeleton - metabolism
Endosomal Sorting Complexes Required for Transport - metabolism
Filaments
Humans
Intermediate filaments
Intermediate Filaments - metabolism
JNK Mitogen-Activated Protein Kinases - metabolism
Kinases
Medical research
Microtubules
Microtubules - metabolism
Phosphatase
Phosphorylation
Proteins
Review
Septins - metabolism
Spectrin
Spectrin - metabolism
Transcription factors
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Summary:This review extensively reports data from the literature concerning the complex relationships between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton elements, which are actin filaments, microtubules, intermediate filaments, and septins. To a lesser extent, we also focused on the two membrane-associated cytoskeletons spectrin and ESCRT-III. We gather the mechanisms controlling cytoskeleton-associated JNK activation and the known cytoskeleton-related substrates directly phosphorylated by JNK. We also point out specific locations of the JNK upstream regulators at cytoskeletal components. We finally compile available techniques and tools that could allow a better characterization of the interplay between the different types of cytoskeleton filaments upon JNK-mediated stress and during development. This overview may bring new important information for applied medical research.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22168375