Testosterone Replacement Therapy in Hypogonadal Men and Myocardial Infarction Risk: Systematic Review & Meta-Analysis

Testosterone replacement therapy (TRT) has become increasingly popular over the years and there has been an increasing debate on whether testosterone replacement should be offered to older men due to its association with cardiovascular events. In this study, we evaluated the risk of myocardial infar...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2021-08, Vol.13 (8), p.e17475
Main Authors: Lee, Jun Hee, Shah, Prutha H, Uma, Davuluri, Salvi, Dhairya J, Rabbani, Rizwan, Hamid, Pousette
Format: Article
Language:English
Subjects:
Cardiology
Internal Medicine
Urology
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Summary:Testosterone replacement therapy (TRT) has become increasingly popular over the years and there has been an increasing debate on whether testosterone replacement should be offered to older men due to its association with cardiovascular events. In this study, we evaluated the risk of myocardial infarction (MI) associated with TRT in hypogonadal men through a meta-analysis. We carried out the analysis by following the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines and conducted a literature search utilizing the following databases: Google Scholar, PubMed, Science Direct, Cochrane Library trials, and ClinicalTrials.gov. The search strategy resulted in a total of 782 articles, after applying our inclusion and exclusion criteria. Six observational studies and two randomized controlled trials (RCTs) were included for the analysis. A total of 55,806 hypogonadal men with baseline testosterone levels
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.17475