Assessment of the Cytotoxic Activity of Triphala: A Semisolid Traditional Formulation on HepG2 Cancer Cell Line

Cancer chemotherapies may result in resistance, and therefore, contemporary treatments including natural products may find an increasing consideration. As per Persian medicine (PM), many natural products have been used for malignant and chronic diseases. Triphala, with a combination of Terminalia ch...

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Bibliographic Details
Published in:BioMed research international 2021-08, Vol.2021, p.1-7
Main Authors: Sahragard, Ali, Alavi, Zohreh, Abolhassanzadeh, Zohreh, Moein, Mahmoodreza, Mohammadi-Bardbori, Afshin, Omidi, Mahmoud, Zarshenas, Mohammad M.
Format: Article
Language:English
Subjects:
Alternative medicine
Anticancer properties
Biomedical research
Cancer
Cancer therapies
Cell growth
Chronic illnesses
Cisplatin
Cytotoxicity
Drugs
Fruits
Hepatocytes
Herbal medicine
Liver cancer
Natural products
Semisolids
Statistical analysis
Survival
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Summary:Cancer chemotherapies may result in resistance, and therefore, contemporary treatments including natural products may find an increasing consideration. As per Persian medicine (PM), many natural products have been used for malignant and chronic diseases. Triphala, with a combination of Terminalia chebula Retz., Terminalia bellirica Retz., Phyllanthus emblica L., and honey, is a multi-ingredient traditional formulation attributed to anticancer activities in PM. This study is aimed at evaluating the cytotoxic activity of this preparation on HepG2, the human liver cancer cell line. Hydroalcoholic extracts were prepared from the formulation and its components. Compared with the control and Cisplatin, the extracts were tested using MTT assay at different concentrations. All concentrations of the preparation, as well as Cisplatin, were effective significantly against HepG2 cells. All extract preparations at multiple concentrations were significantly effective as evidenced by MTT assay when compared to the control group. The IC50 level for Triphala extract was 77.63±4.3 μg/ml. Based on the results, Triphala and its components have cytotoxic activity on the HepG2 cancer cell line and they can reduce the survival rate significantly.
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/6689568