Prognostic and Immunological Role of THBS2 in Colorectal cancer

Objective. Thrombospondin 2 (THBS2) acts as oncogenic or tumor suppressive gene in diverse cancers. Here we studied the prognostic and immunological role of THBS2 in colorectal cancer (CRC) using bioinformatic analysis. Methods. The genetic and protein expression of THBS2 in CRC were explored across...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021, p.1124985-11
Main Authors: Deng, Bin, Liu, Xiu-Ping, Wang, Xiong
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Angiogenesis
Biomarkers
Biomarkers, Tumor - metabolism
Biomedical research
Cancer
Care and treatment
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - immunology
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Computational Biology - methods
Databases, Genetic
Datasets
Dendritic cells
Development and progression
Esophagus
Extracellular matrix
Gene expression
Genetic analysis
Genetic aspects
Glycoproteins
Health aspects
Humans
Immune response
Immunology
Infiltration
Lymphocytes
Lymphocytes, Tumor-Infiltrating - immunology
Medical prognosis
Metastases
Metastasis
Neutrophils
Oncology, Experimental
Prognosis
Protein expression
Proteins
Survival analysis
Survival Rate
Thrombospondin
Thrombospondins - immunology
Thrombospondins - metabolism
Tumor suppressor genes
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Summary:Objective. Thrombospondin 2 (THBS2) acts as oncogenic or tumor suppressive gene in diverse cancers. Here we studied the prognostic and immunological role of THBS2 in colorectal cancer (CRC) using bioinformatic analysis. Methods. The genetic and protein expression of THBS2 in CRC were explored across several databases, including ONCOMINE, GEPIA2, TIMER 2.0, UALCAN and HPA databases. Correlation between THBS2 expression and clinical features in CRC was assessed using UALCAN tool. Prognostic analysis was performed using GEPIA2 and PrognoScan. Immune infiltration correlation with THBS2 in CRC was investigated with TIMER 2.0 and TISIDB. THBS2 binding and correlated genes were analyzed using String, GEPIA2, and TIMER 2.0. Results. THBS2 was significantly higher in CRC across multiple databases. Age and histological subtype were correlated with THBS2 level. High THBS2 expression correlated with short overall and disease-free survival. THBS2 expression was positively correlated with immune infiltrates in CRC. Moreover, extracellular matrix structural constituent and organization, PI3K-Akt pathway, were involved in the functional mechanisms of THBS2. Conclusions. THBS2 correlates with poor prognosis and immune infiltration in CRC. THBS2 may act as a prognostic and immunological biomarker for CRC.
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/1124985