Multiomics: unraveling the panoramic landscapes of SARS-CoV-2 infection

In response to emerging infectious diseases, such as the recent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is critical to quickly identify and understand responsible pathogens, risk factors, host immune responses, and pa...

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Bibliographic Details
Published in:Cellular & molecular immunology 2021-10, Vol.18 (10), p.2313-2324
Main Authors: Wang, Xin, Xu, Gang, Liu, Xiaoju, Liu, Yang, Zhang, Shuye, Zhang, Zheng
Format: Article
Language:English
Subjects:
631/250/255/2514
631/80/304
Antibodies
Biomedical and Life Sciences
Biomedicine
Coronaviruses
COVID-19
COVID-19 - genetics
COVID-19 - immunology
COVID-19 - metabolism
COVID-19 - pathology
Drug development
Genomics
Host-Pathogen Interactions
Humans
Immune response
Immunology
Immunosuppressive agents
Infectious diseases
Medical Microbiology
Metabolomics
Microbiology
Pandemics
Pathogens
Proteomics
Review
Review Article
Risk factors
SARS-CoV-2 - physiology
Severe acute respiratory syndrome coronavirus 2
Single-Cell Analysis
Transcriptome
Vaccine
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Summary:In response to emerging infectious diseases, such as the recent pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is critical to quickly identify and understand responsible pathogens, risk factors, host immune responses, and pathogenic mechanisms at both the molecular and cellular levels. The recent development of multiomic technologies, including genomics, proteomics, metabolomics, and single-cell transcriptomics, has enabled a fast and panoramic grasp of the pathogen and the disease. Here, we systematically reviewed the major advances in the virology, immunology, and pathogenic mechanisms of SARS-CoV-2 infection that have been achieved via multiomic technologies. Based on well-established cohorts, omics-based methods can greatly enhance the mechanistic understanding of diseases, contributing to the development of new diagnostics, drugs, and vaccines for emerging infectious diseases, such as COVID-19.
ISSN:1672-7681
2042-0226
DOI:10.1038/s41423-021-00754-0