Histopathological patterns in atypical teratoid/rhabdoid tumors are related to molecular subgroup

Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor that may not only contain rhabdoid tumor cells but also poorly differentiated small‐round‐blue cells as well as areas with mesenchymal or epithelial differentiation. Little is known on factors associated with histopathological dive...

Full description

Saved in:
Bibliographic Details
Published in:Brain pathology (Zurich, Switzerland) Switzerland), 2021-09, Vol.31 (5), p.e12967-n/a
Main Authors: Zin, Francesca, Cotter, Jennifer A., Haberler, Christine, Dottermusch, Matthias, Neumann, Julia, Schüller, Ulrich, Schweizer, Leonille, Thomas, Christian, Nemes, Karolina, Johann, Pascal D., Kool, Marcel, Frühwald, Michael C., Paulus, Werner, Judkins, Alexander, Hasselblatt, Martin
Format: Article
Language:English
Subjects:
Adolescent
Adult
AT/RT
Biomarkers, Tumor - genetics
Cell differentiation
Central Nervous System Neoplasms - genetics
Central Nervous System Neoplasms - pathology
Child
Cytokeratin
DNA fingerprinting
DNA methylation
DNA Methylation - genetics
DNA methylation profiling
Female
histopathology
Humans
INI‐1
Keratin
Male
Mesenchyme
Methylation
Morphology
Myc protein
Neoplasms, Neuroepithelial - genetics
Neoplasms, Neuroepithelial - pathology
Observers
Rhabdoid Tumor - pathology
SMARCB1 Protein - genetics
Stem cells
Subgroups
Teratoma - pathology
Tumor cells
Tumors
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant tumor that may not only contain rhabdoid tumor cells but also poorly differentiated small‐round‐blue cells as well as areas with mesenchymal or epithelial differentiation. Little is known on factors associated with histopathological diversity. Recent studies demonstrated three molecular subgroups of AT/RT, namely ATRT‐TYR, ATRT‐SHH, and ATRT‐MYC. We thus aimed to investigate if morphological patterns might be related to molecular subgroup status. Hematoxylin‐eosin stained sections of 114 AT/RT with known molecular subgroup status were digitalized and independently categorized by nine blinded observers into four morphological categories, that is, “rhabdoid,” “small‐round‐blue,” “epithelial,” and “mesenchymal.” The series comprised 48 ATRT‐SHH, 40 ATRT‐TYR, and 26 ATRT‐MYC tumors. Inter‐observer agreement was moderate but significant (Fleiss’ kappa = 0.47; 95% C.I. 0.41‐0.53; p 
ISSN:1015-6305
1750-3639
DOI:10.1111/bpa.12967