Implications of the COVID-19 pandemic for people with bipolar disorders: A scoping review

• Published in: Journal of affective disorders 2021-12, Vol.295, p.740-751
• Main Authors: Fornaro, Michele, De Prisco, Michele, Billeci, Martina, Ermini, Eleonora, Young, Allan H, Lafer, Beny, Soares, Jair C., Vieta, Eduard, Quevedo, Joao, de Bartolomeis, Andrea, Sim, Kang, Yatham, Lakshmi N, Bauer, Michael, Stein, Dan J., Solmi, Marco, Berk, Michael, Carvalho, Andre F.
• Format: Article
• Language: English
• Subjects: Bipolar Disorder - epidemiology; COVID-19; Depressive Disorder, Major; Humans; Pandemics; Review; SARS-CoV-2
• ISSN: 0165-0327; 1573-2517; 1573-2517
• DOI: 10.1016/j.jad.2021.08.091

•The lives and care of people with bipolar disorders have been impacted by the COVID-19 pandemic.•We conducted a scoping review of the available literature.•Several themes were identified and further themes were suggested for further inquiry.•There is a pressing need for more high-quality research in this priority area. The COVID-19 (coronavirus disease 2019)-related pandemic represents a global source of societal and health burden. Yet, the impact of the pandemic on people with severe mental illness, including bipolar disorder (BD), remains unclear, warranting scoping review on the matter. The MEDLINE and EMBASE databases were systematically searched from inception up to April 24, 2021, adopting broad inclusion criteria to assess a variety of clinical and public health themes related to people with a primary diagnosis of BD during the COVID-19 pandemics. The present work complying with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) registered in the Open Science Framework (OSF) repository (https://osf.io/7evpx/). Fourteen papers informed the present scoping review. Four major themes were identified: (i) impact of COVID-19-related stressors on BD; (ii) impact of COVID-19 on mental health service utilization among people with BD; (iii) impact of BD on the risk of acquiring SARS-CoV-2 infection; (iv) engagement in preventative behaviors among people with BD. Additional themes warranting further research were nonetheless detected. Further original studies are needed. The present study confirmed the high-vulnerability hypothesis concerning people with BD versus the general population, reinforcing the need for further research related to the COVID-19 pandemic. Additional information is warranted to compare the impact of the pandemic period among BD people against pre-pandemic records, the general population, and other severe mental illnesses, namely people with schizophrenia or major depressive disorder, to inform the public health and the delivery of patient-tailored interventions.