Establishing a reproductive biorepository for basic and translational research: experience developing the reproductive subjects registry and sample repository

Purpose To report experience designing and establishing a reproductive registry and sample biorepository and to describe initial subject characteristics and biospecimens. Methods Beginning in December 2017, patients presenting for reproductive care at the University of Michigan were approached for s...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2021-08, Vol.38 (8), p.2097-2105
Main Authors: Schon, Samantha B., Raja, Nicholas, Xu, Min, Cameron, Heather, Yang, Kun, Reynolds, Jayne, Fenner, Dee, Marsh, Erica E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biobanks
Consent
Data collection
Endocrinology
Enrollments
Female
Fertility
Follicular fluid
Granulosa cells
Gynecology
Health care
Human Genetics
Humans
In vitro fertilization
Infertility
Initiatives
Male
Medicine
Medicine & Public Health
Middle Aged
Obstetrics
Oocytes
Pathophysiology
Patients
Phlebotomy
Precision medicine
Registries - statistics & numerical data
Reproduction
Reproductive health
Reproductive Medicine
Reproductive Physiology and Disease
Specimen Handling - methods
Surgery
Surveys and Questionnaires
Tissue Banks - organization & administration
Tissue Banks - statistics & numerical data
Translation
Translational Research, Biomedical - standards
Urine
Uterus
Young Adult
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Summary:Purpose To report experience designing and establishing a reproductive registry and sample biorepository and to describe initial subject characteristics and biospecimens. Methods Beginning in December 2017, patients presenting for reproductive care at the University of Michigan were approached for study enrollment. Following consent, subjects completed detailed reproductive and health questionnaires. A variety of reproductive specimens and tissues were collected and processed for multiple downstream applications. Results Subject enrollment began in December of 2017. There are currently 1798 subjects enrolled. Female participants report a variety of reproductive disorders. Available samples include semen, sperm, follicular fluid, granulosa cells, immature oocytes, ovarian and uterine tissue, and blood samples. Conclusion We report the successful establishment of a reproductive registry and sample biorepository. Furthermore, we describe methods for collection and storage of a variety of reproductive tissue processed for multiple downstream translational applications.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-021-02165-6