Long noncoding RNAs in respiratory viruses: A review

Long noncoding RNAs (lncRNAs) are defined as RNA molecules longer than 200 nucleotides that can regulate gene expression at the transcriptional or post‐transcriptional levels. Both human lncRNAs and lncRNAs encoded by viruses can modulate the expression of host genes which are critical for viral rep...

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Bibliographic Details
Published in:Reviews in medical virology 2022-03, Vol.32 (2), p.e2275-n/a
Main Authors: Kesheh, Mina Mobini, Mahmoudvand, Shahab, Shokri, Somayeh
Format: Article
Language:English
Subjects:
Chemokines
Coronaviruses
COVID-19
Gene expression
Humans
IAV
Influenza A
Influenza A virus - genetics
Interferon
Interferons - genetics
Latency
long noncoding RNAs
Non-coding RNA
Nucleotides
Respiratory syncytial virus
respiratory viruses
Review
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
RNA-mediated interference
RSV
SARS-CoV-2 - genetics
SARS‐CoV‐2
Severe acute respiratory syndrome coronavirus 2
Signal transduction
Transcription
Virus Replication
Viruses
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Summary:Long noncoding RNAs (lncRNAs) are defined as RNA molecules longer than 200 nucleotides that can regulate gene expression at the transcriptional or post‐transcriptional levels. Both human lncRNAs and lncRNAs encoded by viruses can modulate the expression of host genes which are critical for viral replication, latency, activation of signalling pathways, cytokine and chemokine production, RNAi processing, expression of interferons (IFNs) and interferon‐stimulated genes (ISGs). Studies on lncRNAs as key regulators of host‐virus interactions may give new insights into therapeutic strategies for the treatment of related diseases. This current review focuses on the role of lncRNAs, and their interactions with respiratory viruses including influenza A virus (IAV), respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
ISSN:1052-9276
1099-1654
DOI:10.1002/rmv.2275