Clinical effectiveness of COVID‐19 vaccination in solid organ transplant recipients

• Published in: Transplant Infectious Disease 2021-10, Vol.23 (5), p.e13705-n/a
• Main Authors: Aslam, Saima, Adler, Eric, Mekeel, Kristin, Little, Susan J.
• Format: Article
• Language: English
• Subjects: Brief Communication; Coronaviruses; COVID-19; COVID-19 vaccines; Demography; Immunization; mRNA; SARS‐CoV‐2; Solid organ transplant; Vaccination; vaccine; Viral diseases
• ISSN: 1398-2273; 1399-3062
• DOI: 10.1111/tid.13705

Goal We aimed to assess the incidence rate of coronavirus disease 2019 (COVID‐19) in vaccinated versus unvaccinated solid organ transplant recipients (SOTR) at our center. Methods We ed the following clinical data from our transplant registry from 1/1/2021 to 6/2/2021: demographics, details of COVID‐19 vaccination, incidence of COVID‐19, and related mortality. We calculated incidence of symptomatic COVID‐19 per 1000/person days at risk and incidence rate ratio (IRR). Results Among 2151 SOTRs, 912 were fully vaccinated, and 1239 were controls (1151 unvaccinated, 88 partially vaccinated). Almost 70% of vaccinated subjects received the mRNA‐1273 vaccine. There were 65 cases of COVID‐19 that occurred during the study period – four occurred among fully vaccinated individuals and 61 among controls (including two in partially vaccinated individuals). Incidence rate for COVID‐19 was 0.065 (95% CI 0.024–0.17) per 1000 person days in vaccinated versus 0.34 (95% CI 0.26–0.44) per 1000/person days in the control group; IRR was 0.19 (95% CI 0.049 −0.503, p