Plasmonic Sensors for Extracellular Vesicle Analysis: From Scientific Development to Translational Research

Extracellular vesicles (EVs), actively shed from a variety of neoplastic and host cells, are abundant in blood and carry molecular markers from parental cells. For these reasons, EVs have gained much interest as biomarkers of disease. Among a number of different analytical methods that have been dev...

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Bibliographic Details
Published in:ACS nano 2020-11, Vol.14 (11), p.14528-14548
Main Authors: Chin, Lip Ket, Son, Taehwang, Hong, Jae-Sang, Liu, Ai-Qun, Skog, Johan, Castro, Cesar M, Weissleder, Ralph, Lee, Hakho, Im, Hyungsoon
Format: Article
Language:English
Subjects:
Biomarkers
Extracellular Vesicles
Spectrum Analysis, Raman
Surface Plasmon Resonance
Translational Research, Biomedical
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Summary:Extracellular vesicles (EVs), actively shed from a variety of neoplastic and host cells, are abundant in blood and carry molecular markers from parental cells. For these reasons, EVs have gained much interest as biomarkers of disease. Among a number of different analytical methods that have been developed, surface plasmon resonance (SPR) stands out as one of the ideal techniques given its sensitivity, robustness, and ability to miniaturize. In this Review, we compare different SPR platforms for EV analysis, including conventional SPR, nanoplasmonic sensors, surface-enhanced Raman spectroscopy, and plasmonic-enhanced fluorescence. We discuss different surface chemistries used to capture targeted EVs and molecularly profile their proteins and RNAs. We also highlight these plasmonic platforms’ clinical applications, including cancers, neurodegenerative diseases, and cardiovascular diseases. Finally, we discuss the future perspective of plasmonic sensing for EVs and their potentials for commercialization and clinical translation.
ISSN:1936-0851
1936-086X
1936-086X
DOI:10.1021/acsnano.0c07581