The contribution of YTHDF2 gene rs3738067 A>G to the Wilms tumor susceptibility

YTHDF2 is responsible for maintaining the dynamic N6-methyladenosine (m6A) modification balance and influences a variety of cancers. We tested whether YTHDF2 gene rs3738067 A>G polymorphism is related to Wilms tumor by genotyping samples of Chinese children (450 cases and 1317 controls). However,...

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Bibliographic Details
Published in:Journal of Cancer 2021-01, Vol.12 (20), p.6165-6169
Main Authors: Wang, Zhiyuan, Zhuo, Zhenjian, Li, Linyan, Hua, Rui-Xi, Li, Li, Zhang, Jiao, Cheng, Jiwen, Zhou, Haixia, Li, Suhong, He, Jing, Yan, Shan
Format: Article
Language:English
Subjects:
Age
Binding sites
Confidence intervals
Gender
Genotype & phenotype
Liver cancer
Mutation
Polymorphism
Proteins
Quality control
Research Paper
Variables
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Summary:YTHDF2 is responsible for maintaining the dynamic N6-methyladenosine (m6A) modification balance and influences a variety of cancers. We tested whether YTHDF2 gene rs3738067 A>G polymorphism is related to Wilms tumor by genotyping samples of Chinese children (450 cases and 1317 controls). However, the rs3738067 A>G polymorphism showed no statistical significance with Wilms tumor susceptibility. Stratification analysis also revealed that there was no remarkable association of rs3738067 variant AG/GG genotype with Wilms tumor risk in every subgroup (age, gender, and clinical stages). In all, the results indicated YTHDF2 gene rs3738067 A>G polymorphism could not alter Wilms tumor risk significantly.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.62154