Corrigendum: Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine

• Published in: Angewandte Chemie International Edition 2021-07, Vol.60 (31), p.16741-16742
• Main Authors: Jangra, Sonia, De Vrieze, Jana, Choi, Angela, Rathnasinghe, Raveen, Laghlali, Gabriel, Uvyn, Annemiek, Van Herck, Simon, Nuhn, Lutz, Deswarte, Kim, Zhong, Zifu, Sanders, Niek N., Lienenklaus, Stefan, David, Sunil A., Strohmeier, Shirin, Amanat, Fatima, Krammer, Florian, Hammad, Hamida, Lambrecht, Bart N., Coughlan, Lynda, García‐Sastre, Adolfo, De Geest, Bruno G., Schotsaert, Michael
• Format: Article
• Language: English
• Subjects: amphiphiles; Corrigendum; COVID-19; innate immunity; SARS-CoV-2; vaccines
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.202105635

See PDF.] The sentence “Furthermore, compared to IMDQ-PEG, IMDQ-PEG was more potent in inducing NF-kB activation in a reporter cell line (Figure 2 D), while being non-toxic within the tested experimental window (Figure 2 E)” should be replaced by “Furthermore, compared to IMDQ-PEG, IMDQ-PEG-CHOL was more potent in inducing NF-κB activation in a reporter cell line (Figure 2 D), while being non-toxic within the tested experimental window (Figure 2 E)”. In Figure 3 A the panels corresponding to the IMDQ-PEG-CHOL and IMDQ (but not IMDQ-PEG) groups were mistakenly copied from a previous manuscript of our group.1 Note that in analogy to our findings in Ref. [1], conjugation of IMDQ to an amphiphilic lipid-polymer carrier, again appeared crucial for mediating lymphatic translocation as the non-amphiphilic IMDQ-PEG induced very limited activity in the draining lymph node. See PDF.] Figure S3 in the Supporting Information has been expanded with ROI (=region of interest) designation on the bioluminescence images and a table containing the individual photon flux values from the draining popliteal lymph node and the whole body of the animals.