Imaging of Pancreatic Neuroendocrine Neoplasms

Pancreatic neuroendocrine neoplasms (panNENs) represent the second most common pancreatic tumors. They are a heterogeneous group of neoplasms with varying clinical expression and biological behavior, from indolent to aggressive ones. PanNENs can be functioning or non-functioning in accordance with t...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-08, Vol.18 (17), p.8895
Main Authors: Chiti, Giuditta, Grazzini, Giulia, Cozzi, Diletta, Danti, Ginevra, Matteuzzi, Benedetta, Granata, Vincenza, Pradella, Silvia, Recchia, Laura, Brunese, Luca, Miele, Vittorio
Format: Article
Language:English
Subjects:
Biopsy
Classification
Computed tomography
Emission analysis
Endoscopy
Hormones
Imaging techniques
Localization
Magnetic resonance imaging
Medical imaging
Medical prognosis
Metastasis
Mutation
Neoplasms
Neuroendocrine tumors
Pancreas
Pancreatic cancer
Positron emission
Positron emission tomography
Radiomics
Review
Scintigraphy
Somatostatin
Tomography
Tumors
Ultrasonic imaging
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Summary:Pancreatic neuroendocrine neoplasms (panNENs) represent the second most common pancreatic tumors. They are a heterogeneous group of neoplasms with varying clinical expression and biological behavior, from indolent to aggressive ones. PanNENs can be functioning or non-functioning in accordance with their ability or not to produce metabolically active hormones. They are histopathologically classified according to the 2017 World Health Organization (WHO) classification system. Although the final diagnosis of neuroendocrine tumor relies on histologic examination of biopsy or surgical specimens, both morphologic and functional imaging are crucial for patient care. Morphologic imaging with ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) is used for initial evaluation and staging of disease, as well as surveillance and therapy monitoring. Functional imaging techniques with somatostatin receptor scintigraphy (SRS) and positron emission tomography (PET) are used for functional and metabolic assessment that is helpful for therapy management and post-therapeutic re-staging. This article reviews the morphological and functional imaging modalities now available and the imaging features of panNENs. Finally, future imaging challenges, such as radiomics analysis, are illustrated.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18178895