Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer

Interferon (IFN)-γ-inducible chemokines in the CXCR3/ligand axis are involved in cell-mediated immunity and play a significant role in the progression of cancer. We enrolled patients with lung cancer (n = 144) and healthy volunteers as the controls (n = 140). Initial blood samples were collected and...

Full description

Saved in:
Bibliographic Details
Published in:International journal of environmental research and public health 2021-09, Vol.18 (17), p.9345
Main Authors: Lee, Keu-Sung, Chung, Wou-Young, Park, Ji-Eun, Jung, Yun-Jung, Park, Joo-Hun, Sheen, Seung-Soo, Park, Kwang-Joo
Format: Article
Language:English
Subjects:
Cell-mediated immunity
Chemokines
CXCL10 protein
CXCL11 protein
CXCR3 protein
Enzyme-linked immunosorbent assay
Interferon
Ligands
Lung cancer
Markers
Medical prognosis
Metastases
Multivariate analysis
Non-small cell lung carcinoma
Patients
Statistical analysis
Survival
Survival analysis
Tumors
γ-Interferon
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Interferon (IFN)-γ-inducible chemokines in the CXCR3/ligand axis are involved in cell-mediated immunity and play a significant role in the progression of cancer. We enrolled patients with lung cancer (n = 144) and healthy volunteers as the controls (n = 140). Initial blood samples were collected and concentrations of IFN-γ and IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 were measured using enzyme-linked immunosorbent assay. Of patients with lung cancer, 125 had non-small cell lung cancer (NSCLC) and 19 had small cell lung cancer. The area under the curve (AUC) (95% CI) of CXCL9 was 0.83 (0.80–0.89) for differentiating lung cancer patients from controls. The levels of all the markers were significantly higher in NSCLC patients with stage IV than in those with stages I–III. A Kaplan-Meier survival analysis showed that NSCLC cancer patients with higher levels of all markers showed poorer survival than those with lower levels. In Cox multivariate analysis of patients with NSCLC, independent prognostic factors for overall survival were CXCL9 and CXCL11. CXCL9 was the only independent prognostic factor for cancer-specific survival. Serum IFN-γ-inducible chemokines may be useful as clinical markers of metastasis and prognosis in NSCLC, and CXCL9 levels showed the most significant results.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18179345