Effect of Preterm Birth on Cardiac and Cardiomyocyte Growth and the Consequences of Antenatal and Postnatal Glucocorticoid Treatment

Preterm birth coincides with a key developmental window of cardiac growth and maturation, and thus has the potential to influence long-term cardiac function. Individuals born preterm have structural cardiac remodelling and altered cardiac growth and function by early adulthood. The evidence linking...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-08, Vol.10 (17), p.3896
Main Authors: Vrselja, Amanda, Pillow, J. Jane, Black, M. Jane
Format: Article
Language:English
Subjects:
Birth weight
Blood pressure
Cardiomyocytes
Cardiovascular disease
Child development
Clinical medicine
Gestational age
Heart rate
Hypertension
Newborn babies
Polyploidy
Premature birth
Review
Sheep
Young adults
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Summary:Preterm birth coincides with a key developmental window of cardiac growth and maturation, and thus has the potential to influence long-term cardiac function. Individuals born preterm have structural cardiac remodelling and altered cardiac growth and function by early adulthood. The evidence linking preterm birth and cardiovascular disease in later life is mounting. Advances in the perinatal care of preterm infants, such as glucocorticoid therapy, have improved survival rates, but at what cost? This review highlights the short-term and long-term impact of preterm birth on the structure and function of the heart and focuses on the impact of antenatal and postnatal glucocorticoid treatment on the immature preterm heart.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10173896