Performance characteristics of an enzyme-linked immunosorbent assay for determining salivary immunoglobulin G response to Helicobacter pylori

We evaluated the salivary immunoglobulin G (IgG) immune response to Helicobacter pylori in 70 subjects by enzyme-linked immunosorbent assay (ELISA). Subjects with a positive H. pylori culture showed significantly higher titers of antibodies than subjects with no detectable H. pylori: the overall sen...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical microbiology 1999-02, Vol.37 (2), p.430-432
Main Authors: DE PASCALIS, R, DEL PEZZO, M, NARDONE, G, BUDILLON, G, LAVITOLA, A
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - analysis
Antibodies, Bacterial - blood
Bacterial diseases
Bacterial diseases of the digestive system and abdomen
Bacteriology
Biological and medical sciences
Culture Media
Enzyme-Linked Immunosorbent Assay - methods
Evaluation Studies as Topic
Helicobacter Infections - diagnosis
Helicobacter Infections - immunology
Helicobacter pylori
Helicobacter pylori - immunology
Helicobacter pylori - isolation & purification
Human bacterial diseases
Humans
Immunoglobulin G - analysis
Immunoglobulin G - blood
Infectious diseases
Medical sciences
Saliva - immunology
Saliva - microbiology
Sensitivity and Specificity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We evaluated the salivary immunoglobulin G (IgG) immune response to Helicobacter pylori in 70 subjects by enzyme-linked immunosorbent assay (ELISA). Subjects with a positive H. pylori culture showed significantly higher titers of antibodies than subjects with no detectable H. pylori: the overall sensitivity and specificity of the test were 84 and 90%, respectively. The detection of salivary anti-H. pylori IgG antibodies may be considered as an alternative to serum IgG detection for ease of sample collection or when blood samples are not available in screening of patients with dyspepsia.
ISSN:0095-1137
1098-660X
DOI:10.1128/jcm.37.2.430-432.1999