Metabolomics: The Stethoscope for the Twenty-First Century

Metabolomics encompasses the systematic identification and quantification of all metabolic products in the human body. This field could provide clinicians with novel sets of diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualized lev...

Full description

Saved in:
Bibliographic Details
Published in:Medical principles and practice 2021-08, Vol.30 (4), p.301-310
Main Authors: Ashrafian, Hutan, Sounderajah, Viknesh, Glen, Robert, Ebbels, Timothy, Blaise, Benjamin J., Kalra, Dipak, Kultima, Kim, Spjuth, Ola, Tenori, Leonardo, Salek, Reza M., Kale, Namrata, Haug, Kenneth, Schober, Daniel, Rocca-Serra, Philippe, O’Donovan, Claire, Steinbeck, Christoph, Cano, Isaac, de Atauri, Pedro, Cascante, Marta
Format: Article
Language:English
Subjects:
Chromatography
Clinical medicine
Humans
Medical Biochemistry
Medical research
Medicinsk biokemi
Metabolism
Metabolites
Metabolomics
Methods
NMR
Nuclear magnetic resonance
Personalised medicine
Precision Medicine
Principal components analysis
R&D
Research & development
Review
Statistical analysis
Stethoscopes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Metabolomics encompasses the systematic identification and quantification of all metabolic products in the human body. This field could provide clinicians with novel sets of diagnostic biomarkers for disease states in addition to quantifying treatment response to medications at an individualized level. This literature review aims to highlight the technology underpinning metabolic profiling, identify potential applications of metabolomics in clinical practice, and discuss the translational challenges that the field faces. We searched PubMed, MEDLINE, and EMBASE for primary and secondary research articles regarding clinical applications of metabolomics. Metabolic profiling can be performed using mass spectrometry and nuclear magnetic resonance-based techniques using a variety of biological samples. This is carried out in vivo or in vitro following careful sample collection, preparation, and analysis. The potential clinical applications constitute disruptive innovations in their respective specialities, particularly oncology and metabolic medicine. Outstanding issues currently preventing widespread clinical use are scalability of data interpretation, standardization of sample handling practice, and e-infrastructure. Routine utilization of metabolomics at a patient and population level will constitute an integral part of future healthcare provision.
ISSN:1011-7571
1423-0151
1423-0151
DOI:10.1159/000513545