Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer’s Disease

Alzheimer’s disease (AD) is the most common type of dementia. Currently, more than 50 million people live with dementia worldwide, and this number is expected to increase. Some of the typical pathological changes of AD include amyloid plaque, hyperphosphorylation of tau protein, secretion of inflamm...

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Bibliographic Details
Published in:Neurochemical research 2022-02, Vol.47 (2), p.205-217
Main Authors: Wan, Teng, Fu, Mingyuan, Jiang, Yan, Jiang, Weiwei, Li, Peiling, Zhou, Shouhong
Format: Article
Language:English
Subjects:
Alzheimer Disease - drug therapy
Alzheimer Disease - metabolism
Alzheimer Disease - prevention & control
Alzheimer's disease
Amyloid
Angiotensin
Apelin Receptors
Apoptosis
Autophagy
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Dementia
Dementia disorders
Humans
Inflammation
Intercellular Signaling Peptides and Proteins - therapeutic use
Neurochemistry
Neurodegenerative diseases
Neurology
Neuroprotection
Neurosciences
Phosphorylation
Prevention
Proteins
Review
Synaptic plasticity
Tau protein
tau Proteins - metabolism
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Summary:Alzheimer’s disease (AD) is the most common type of dementia. Currently, more than 50 million people live with dementia worldwide, and this number is expected to increase. Some of the typical pathological changes of AD include amyloid plaque, hyperphosphorylation of tau protein, secretion of inflammatory mediators, and neuronal apoptosis. Apelin is a neuroprotective peptide that is widely expressed in the body. Among members of apelin family, apelin-13 is the most abundant with a high neuroprotective function. Apelin-13/angiotensin domain type 1 receptor-associated proteins (APJ) system regulates several physiological and pathophysiological cell activities, such as apoptosis, autophagy, synaptic plasticity, and neuroinflammation. It has also been shown to prevent AD development. This article reviews the research progress on the relationship between apelin-13 and AD to provide new ideas for prevention and treatment of AD.
ISSN:0364-3190
1573-6903
1573-6903
DOI:10.1007/s11064-021-03448-1