Anaphylaxis after rabies vaccination for dogs in Japan

Severe adverse reactions after rabies vaccination in dogs were examined from 317 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 109 of the 317 dogs showed anaphylaxis (0.15/100,000 vaccinated do...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2021, Vol.83(8), pp.1202-1205
Main Authors: YOSHIDA, Megumi, MIZUKAMI, Keijiro, HISASUE, Masaharu, IMANISHI, Ichiro, KURATA, Keigo, OCHIAI, Masaki, ITOH, Masato, NASUKAWA, Tadahiro, UCHIYAMA, Jumpei, TSUJIMOTO, Hajime, SAKAGUCHI, Masahiro
Format: Article
Language:English
Subjects:
adverse reaction
Anaphylaxis
Bovine serum albumin
dog
Immunization
Internal Medicine
Rabies
rabies vaccine
Vaccines
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Summary:Severe adverse reactions after rabies vaccination in dogs were examined from 317 cases reported to the Ministry of Agriculture, Forestry and Fisheries (MAFF) in Japan during 15-year period from April 2004 to March 2019. We found that 109 of the 317 dogs showed anaphylaxis (0.15/100,000 vaccinated dogs), and 71 of the 109 cases of anaphylaxis resulted in death (0.10/100,000 vaccinated dogs). We measured bovine serum albumin (BSA) in four commercially available rabies vaccines and found the levels ranged from 0.1 to 16.6 µg/dose. Our survey showed that the rate of anaphylaxis to rabies vaccines in dogs is rare, although some cases of anaphylaxis resulted in death. Veterinarians should be well prepared to deal with vaccine-associated anaphylaxis.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.21-0090